Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 19/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14981567 | 0.84 | GPR84 (0.49) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL14981558 | 0.84 | GPR84 (0.49) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL25484963 | 0.84 | GPR84 (0.75) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL3922363 | 0.84 | GPR84 (0.72) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL15108783 | 0.83 | GPR84 (0.49) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL296967 | 0.83 | GPR84 (0.74) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL887269 | 0.82 | GPR84 (0.74) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL22256272 | 0.82 | GPR84 (0.72) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL3928881 | 0.81 | GPR84 (0.66) | GPR84MEN1KMT2AKDM4ERECQL | |
| SCHEMBL3917764 | 0.81 | GPR84 (0.84) | GPR84MEN1KMT2AKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598365-B2 | Method for synthesizing cycloalkanyl[b]indoles, cycloalkanyl[b]benzofurans, cycloalkanyl[b]benzothiophenes, compounds and methods of use | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2017-03-21 | — | — | US | disclosed |
| US-9399652-B2 | Synthetic route to pactamycin and pactamycin analogs | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150329570-A1 | SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-19 | — | — | US | disclosed |
| US-20150057326-A1 | Method for Synthesizing Cycloalkanyl[b]indoles, Cycloalkanyl[b]benzofurans, Cycloalkanyl[b]benzothiophenes, Compounds and Methods of Use | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2015-02-26 | — | — | US | disclosed |
| US-8350040-B2 | Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2- methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-01-08 | — | — | US | disclosed |
| EP-1888604-B1 | PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-14 | — | — | EP | disclosed |
| US-20110319623-A1 | PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL | CILAG AG (CH) | 2011-12-29 | — | — | US | disclosed |
| US-8039628-B2 | Isolation from mixture of stereoisomers; optical resolution of enantiomorphs | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-10-18 | — | — | US | disclosed |
| US-7902207-B2 | Process for production of amines | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2011-03-08 | — | — | US | disclosed |
| US-20100311975-A1 | CATIONIC TRANSITION METAL CATALYSTS | KANATA CHEMICAL TECHNOLOGIES INC. (CA) | 2010-12-09 | — | — | US | disclosed |
| US-7799934-B2 | Intermediates (synthons) in the synthesis of pharmaceuticals such as oseltamivir and other products; treating the arizidine with the nucleophile in the presence of a biaryl phosphoric acid catalyst | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-09-21 | — | — | US | disclosed |
| US-7517828-B2 | Chiral broensted acid catalyst for asymmetric synthesis and method of asymmetric synthesis with the catalyst | TOAGOSEI CO., LTD. (JP) | 2009-04-14 | — | — | US | disclosed |
| US-20090030212-A1 | Enantioselective ring-opening of aziridines | UNIVERSITY OF SOUTH FLORIDA OF TAMPA | 2009-01-29 | — | — | US | disclosed |
| WO-2009005775-A2 | ENANTIOSELECTIVE RING-OPENING OF AZIRIDINES | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-01-08 | — | — | WO | disclosed |
| US-20080200683-A1 | Process for Preparing (Alpha S, Beta R)-6-Bromo-Alpha-[2-(Dimethylamino) Ethyl]-2-Methoxy-Alpha-1-Naphthalenyl-Beta-Phenyl-3-Quinolineethanol | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | US | disclosed |
| WO-2007098741-A2 | ORGANIC SALTS AND METHOD FOR PRODUCING CHIRAL ORGANIC COMPOUNDS | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2007-09-07 | — | — | WO | disclosed |
| US-20070142639-A1 | Process for production of amines | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2007-06-21 | — | — | US | disclosed |
| US-20060276329-A1 | Asymmetric synthesis catalyst based on chiral brsnsted acid and method of asymmetric synthesis with the catalyst | TOAGOSEI CO., LTD. (JP) | 2006-12-07 | — | — | US | disclosed |
| EP-1623971-A1 | ASYMMETRIC-SYNTHESIS CATALYST BASED ON CHIRAL BROENSTED ACID AND METHOD OF ASYMMETRIC SYNTHESIS WITH THE CATALYST | TOAGOSEI CO., LTD. (JP) | 2006-02-08 | — | — | EP | disclosed |
| EP-1038877-B1 | Binaphthol monophosphoric acid derivative and its use | TOSOH CORP (JP) | 2004-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329570-A1 | SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS | PAICS, DPM1, MANBA | GPR84 3785/4885MEN1 82/4885KMT2A 977/4885 |
| US-20070142639-A1 | Process for production of amines | SMS, CCNT1, PEAK1 | GPR84 2711/4885MEN1 194/4885KMT2A 2635/4885 |
| US-20060276329-A1 | Asymmetric synthesis catalyst based on chiral brsnsted acid and method of asymmetric synthesis with the catalyst | LSS, COASY, FASN | GPR84 2758/4885MEN1 169/4885KMT2A 2039/4885 |
| US-20090030212-A1 | Enantioselective ring-opening of aziridines | AZI2, ITPA, ADORA2A | GPR84 1418/4885MEN1 647/4885KMT2A 2717/4885 |
| US-20080200683-A1 | Process for Preparing (Alpha S, Beta R)-6-Bromo-Alpha-[2-(Dimethylamino) Ethyl]-2-Methoxy-Alpha-1-Naphthalenyl-Beta-Phenyl-3-Quinolineethanol | LBR, ADRA1A, ADRA1D | GPR84 1474/4885MEN1 1168/4885KMT2A 1760/4885 |
| US-20100311975-A1 | CATIONIC TRANSITION METAL CATALYSTS | AP2M1, OPRM1, CD81 | GPR84 4282/4885MEN1 4031/4885KMT2A 3583/4885 |
| US-20150057326-A1 | Method for Synthesizing Cycloalkanyl[b]indoles, Cycloalkanyl[b]benzofurans, Cycloalkanyl[b]benzothiophenes, Compounds and Methods of Use | CCKBR, GCGR, BDKRB1 | GPR84 577/4885MEN1 882/4885KMT2A 2942/4885 |
| US-20110319623-A1 | PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL | LBR, ADRA1A, ADRA1D | GPR84 1474/4885MEN1 1168/4885KMT2A 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.