SCHEMBL2969282

SCHEMBL2969282

CC1(C2CC2)NC(=O)C(c2cc(-n3cc(Cl)cn3)ccc2Cl)C1=O

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MTOR P42345 2/20 0.34
RPTOR Q8N122 1/20 0.34
MLST8 Q9BVC4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5231679 0.80 L3MBTL1 (0.37)
SCHEMBL2962371 0.74 MKNK2 (0.32) MTORRPTORMLST8
SCHEMBL13097113 0.74 RIPK2 (0.35) MTORRPTORMLST8
SCHEMBL7780304 0.68 TP53 (0.40)
SCHEMBL7781016 0.64 DDB1 (0.36)
SCHEMBL5929376 0.63 L3MBTL1 (0.31)
SCHEMBL5231465 0.63 SLC9A1 (0.41)
SCHEMBL5769406 0.63 L3MBTL1 (0.30)
SCHEMBL13106048 0.62 CYP46A1 (0.33)
SCHEMBL11486255 0.61 NPC1 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100267964-A1 N-HETEROCYCLYLPHENYL-SUBSTITUTED CYCLIC KETOENOLS FISCHER REINER 2010-10-21 US disclosed
US-7776791-B2 N-heterocyclyl phenyl-substituted cyclic ketoenols BAYER CROPSCIENCE AG (DE) 2010-08-17 US disclosed
US-20060166829-A1 N-Heterocycl phenyl-substituted cyclic ketoenols BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2006-07-27 US disclosed
EP-1638957-A1 N-HETEROCYCLYL PHENYL-SUBSTITUTED CYCLIC KETOENOLS Bayer CropScience AG (DE) 2006-03-29 EP disclosed
WO-2004111042-A1 N-HETEROCYCLYL PHENYL-SUBSTITUTED CYCLIC KETOENOLS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100267964-A1 N-HETEROCYCLYLPHENYL-SUBSTITUTED CYCLIC KETOENOLS CYP17A1, CCNY, CCNE2 MTOR 954/4885RPTOR 2147/4885MLST8 1219/4885
US-20060166829-A1 N-Heterocycl phenyl-substituted cyclic ketoenols WEE1, KCNE1, CCNE1 MTOR 1542/4885RPTOR 2971/4885MLST8 3116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.