Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of E626. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 known ✓ | P12268 | 6/20 | 0.65 |
| ▸ | IMPDH1 known ✓ | P20839 | 2/20 | 0.65 |
| ▸ | NT5E | P21589 | 1/20 | 0.79 |
| ▸ | TGM2 | P21980 | 1/20 | 0.73 |
| ▸ | KRAS | P01116 | 8/20 | 0.66 |
| ▸ | HINT1 | P49773 | 1/20 | 0.65 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.65 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.62 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.62 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| E626 SCHEMBL2717837 | 0.94 | NT5E (0.78) | NT5ETGM2KRASHINT1FUT5 | |
| E626 SCHEMBL29899703 | 0.94 | NT5E (0.78) | NT5ETGM2KRASHINT1FUT5 | |
| E626 SCHEMBL1072983 | 0.94 | NT5E (0.78) | NT5ETGM2KRASHINT1FUT5 | |
| E626 SCHEMBL27969015 | 0.94 | NT5E (0.77) | NT5ETGM2KRASHINT1FUT5 | |
| E626 SCHEMBL29804534 | 0.94 | NT5E (0.77) | NT5ETGM2KRASHINT1FUT5 | |
| E626 SCHEMBL9650300 | 0.94 | NT5E (0.77) | NT5ETGM2KRASHINT1FUT5 | |
| E626 SCHEMBL28786050 | 0.94 | NT5E (0.77) | NT5ETGM2KRASHINT1FUT5 | |
| E626 SCHEMBL28495034 | 0.94 | NT5E (0.77) | NT5ETGM2KRASHINT1FUT5 | |
| E626 SCHEMBL3802708 | 0.94 | NT5E (0.77) | NT5ETGM2KRASHINT1FUT5 | |
| SCHEMBL5172376 | 0.93 | NT5E (0.74) | NT5ETGM2KRASHINT1FUT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022127326-A1 | PROTEIN AND MULTI-STAGE POROUS METAL-ORGANIC FRAMEWORK COMPLEX, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 华南理工大学 | 2022-06-23 | — | — | WO | claimed |
| CN-119552844-A | In-vitro two-step enzymatic process for efficiently synthesizing GDP-L-fucose and application thereof | 深圳瑞德林生物技术有限公司 | 2025-03-04 | — | — | CN | disclosed |
| US-20230041289-A1 | COMPOSITIONS AND METHODS FOR ENHANCING OR TREATING FEMALE SEXUAL RESPONSE | T K INC APS (DK) | 2023-02-09 | — | — | US | disclosed |
| WO-2022127326-A1 | PROTEIN AND MULTI-STAGE POROUS METAL-ORGANIC FRAMEWORK COMPLEX, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 华南理工大学 | 2022-06-23 | — | — | WO | disclosed |