Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ACP3 | P15309 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL120227 | 1.00 | KMT2A (0.39) | KMT2ATHRBCYP3A4EPHX1ACP3 | |
| SCHEMBL27822368 | 0.80 | CA1 (0.42) | KMT2AACP3ALDH1A1GAATSHR | |
| SCHEMBL6003200 | 0.80 | ADRA2A (0.35) | KMT2ATHRBALDH1A1LMNAADRA2A | |
| SCHEMBL26689 | 0.79 | KMT2A (0.44) | KMT2ATHRBEPHX1IDO1TDO2 | |
| SCHEMBL27775233 | 0.79 | THRB (0.38) | KMT2ATHRBCYP3A4EPHX1IDO1 | |
| SCHEMBL7292294 | 0.79 | L3MBTL1 (0.41) | KMT2ALMNAL3MBTL1 | |
| SCHEMBL28489517 | 0.78 | AOC3 (0.44) | CYP3A4ALDH1A1L3MBTL1 | |
| SCHEMBL7644220 | 0.78 | SLC6A4 (0.36) | KMT2ALMNAADRA2AADRA2CTSHR | |
| SCHEMBL8698025 | 0.77 | LMNA (0.37) | KMT2AALDH1A1LMNAADRA2AADRA2C | |
| SCHEMBL1129750 | 0.77 | CYP3A4 (0.49) | KMT2ACYP3A4ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772432-B2 | Amidobenzamide derivatives which are useful as cytokine inhibitors | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| US-20090062351-A1 | Benzoyl amino pyridyl carboxylic acid derivatives useful as glucokinase (glk) activators | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | US | disclosed |
| US-20080234273-A1 | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| US-20050038081-A1 | Amidobenzamide derivatives which are useful as cytokine inhibitors | ASTRAZENECA | 2005-02-17 | — | — | US | disclosed |
| EP-1482927-A1 | METHOD OF TREATING OSTEOARTHRITIS | Warner-Lambert Company LLC (US) | 2004-12-08 | — | — | EP | disclosed |
| EP-1469841-A1 | ALPHA 2 DELTA LIGANDS TO TREAT TINNITUS | WARNER-LAMBERT COMPANY (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003074048-A1 | METHOD OF TREATING OSTEOARTHRITIS | WARNER-LAMBERT COMPANY LLC (US) | 2003-09-12 | — | — | WO | disclosed |
| WO-2003063845-A1 | ALPHA 2 DELTA LIGANDS TO TREAT TINNITUS | WARNER-LAMBERT COMPANY LLC (US) | 2003-08-07 | — | — | WO | disclosed |
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038081-A1 | Amidobenzamide derivatives which are useful as cytokine inhibitors | IL6, IL6ST, IL2 | KMT2A 1554/4885THRB 806/4885CYP3A4 360/4885 |
| US-20080234273-A1 | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes | GCK, GCKR, HK1 | KMT2A 1920/4885THRB 1369/4885CYP3A4 397/4885 |
| US-20090062351-A1 | Benzoyl amino pyridyl carboxylic acid derivatives useful as glucokinase (glk) activators | GCK, GCKR, GALK1 | KMT2A 1379/4885THRB 1326/4885CYP3A4 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.