Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Methylene Chloride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL542397 | 1.00 | ALDH1A1 (0.80) | — | |
| Methylene Chloride SCHEMBL4866938 | 1.00 | ALDH1A1 (0.80) | — | |
| Methylene Chloride SCHEMBL11137267 | 1.00 | ALDH1A1 (0.80) | — | |
| Methylene Chloride SCHEMBL7572150 | 1.00 | ALDH1A1 (0.80) | — | |
| Methylene Chloride SCHEMBL4859310 | 1.00 | ALDH1A1 (0.80) | — | |
| Methylene Chloride SCHEMBL20539491 | 1.00 | — | — | |
| Methylene Chloride SCHEMBL7299292 | 1.00 | — | — | |
| Methylene Chloride SCHEMBL542380 | 1.00 | ALDH1A1 (0.80) | — | |
| Methylene Chloride SCHEMBL9259939 | 1.00 | ALDH1A1 (0.80) | — | |
| Methylene Chloride SCHEMBL37645 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2547 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218595-A | A kind of iron iron hydrogenase model thing containing [2P2N] Cu (I) photosensitizers and preparation method thereof | UNIV NANKAI | 2016-01-06 | — | — | CN | claimed |
| CN-105131009-A | I type crystal of L-alanine-(14-rubescensin A)-ester trifluoroacetate, and preparation method thereof | JIANGSU HENGRUI MEDICINE CO | 2015-12-09 | — | — | CN | claimed |
| CN-103570761-A | Copper complex/composite luminescent material sensitive to oxygen gas as well as preparation method thereof and application thereof on oxygen sensing device | UNIV BOHAI | 2014-02-12 | — | — | CN | claimed |
| CN-103539822-A | A synthesis method of cupped metal ring tomato [Rh {9, 10-bis (2-(diphenylphosphino) ethyl) anthracene}-(CO) Cl]3and its application | UNIV NANKAI | 2014-01-29 | — | — | CN | claimed |
| CN-103497209-A | Novel binuclear copper (I) complex blue-light material and method for preparing same | UNIV JIANGXI SCI & TECHNOLOGY | 2014-01-08 | — | — | CN | claimed |
| CN-103112917-A | Method for purifying lead-bearing wastewater | UNIV GUILIN TECH GUT | 2013-05-22 | — | — | CN | claimed |
| CN-1886385-B | Crystals of phenylalanine derivatives and production methods thereof | AJINOMOTO KK | 2013-02-27 | — | — | CN | claimed |
| CN-102603700-A | Method for extracting pseudolaric acid from cortex pseudolaricis | SUZHOU BAOZETANG MEDICAL TECH | 2012-07-25 | — | — | CN | claimed |
| CN-102583485-A | Monodispersed vaterite type calcium carbonate microsphere and preparation method thereof | NANJING UNIVERSITY SUZHOU HIGH TECH INST | 2012-07-18 | — | — | CN | claimed |
| CN-102532407-A | Method for preparing thermal sensitive macromolecules and thermal sensitive nanometer particles with core shell structures through RAFT copolymerization | UNIV SHANGHAI | 2012-07-04 | — | — | CN | claimed |
| CN-102276655-A | Dinitrogen heterocyclic carbene dipalladium coordination compound and preparation method thereof | — | 2011-12-14 | — | — | CN | claimed |
| CN-102180859-A | Method for purifying pseudolaric acid | NANJING ZELANG MEDICAL TECH CO | 2011-09-14 | — | — | CN | claimed |
| CN-101607968-A | Vinflunine salt, its preparation method and pharmaceutical composition thereof | JIANGSU HAOSOH PHARMACEUTICAL (CN) | 2009-12-23 | — | — | CN | claimed |
| CN-100422191-C | Method for separating and preparing triptolide diol from tripterygium wilfordii | UNIV ZHEJIANG (CN) | 2008-10-01 | — | — | CN | claimed |
| CN-1886385-A | Crystals of phenylalanine derivatives and production methods thereof | AJINOMOTO KK (JP) | 2006-12-27 | — | — | CN | claimed |
| CN-1800188-A | Method for separating and preparing triptolide diol from tripterygium wilfordii | UNIV ZHEJIANG (CN) | 2006-07-12 | — | — | CN | claimed |
| CN-1613455-A | Targeting microorgan micro-capsules and their preparation | DONGFANG BAIXIN BIOTECHNOLOGY (CN) | 2005-05-11 | — | — | CN | claimed |
| US-5438064-A | For suppressing the binding of bradykinins to pain receptors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-08-01 | — | — | US | claimed |
| JP-9071575-A | — | — | None | — | — | JP | disclosed |
| JP-H00971575-A | — | — | 0001-01-01 | — | — | JP | disclosed |