Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983082 | 0.98 | ALDH1A1 (0.58) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| SCHEMBL2967553 | 0.97 | ALDH1A1 (0.57) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| SCHEMBL2979886 | 0.97 | ALDH1A1 (0.57) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| SCHEMBL7026429 | 0.97 | ALDH1A1 (0.57) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| SCHEMBL7026439 | 0.97 | ALDH1A1 (0.57) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| SCHEMBL7999063 | 0.95 | ALDH1A1 (0.55) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| Potassium SCHEMBL7999066 | 0.95 | ALDH1A1 (0.55) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| Potassium Ion SCHEMBL31252976 | 0.87 | ALDH1A1 (0.57) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| Potassium Ion SCHEMBL2979881 | 0.87 | NT5E (0.47) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| Potassium Ion SCHEMBL2967551 | 0.87 | NT5E (0.47) | ALDH1A1TDP1CYP3A4ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781611-B2 | Nitro-sulfobenzamides | AVENTIS CROPSCIENCE GMBH (DE) | 2010-08-24 | — | — | US | disclosed |
| EP-1242386-B1 | NITRO-SULFOBENZAMIDES | BAYER CROPSCIENCE AG (DE) | 2009-08-26 | — | — | EP | disclosed |
| US-6518455-B1 | from the corresponding symmetric stilbene compounds of the formula aqueous ozonolysis and subsequent isolation of an aldehyde or oxidation to give the corresponding carboxylic acid. | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-02-11 | — | — | US | disclosed |
| EP-1242386-A1 | NITRO-SULFOBENZAMIDES | Bayer CropScience GmbH (DE) | 2002-09-25 | — | — | EP | disclosed |
| US-20010020092-A1 | Nitro-sulfobenzamides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2001-09-06 | — | — | US | disclosed |
| WO-2001042226-A1 | NITRO-SULFOBENZAMIDES | AVENTIS CROPSCIENCE GMBH (DE) | 2001-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020092-A1 | Nitro-sulfobenzamides | SULT1A1, SULT2A1, SULT1E1 | ALDH1A1 605/4885TDP1 3688/4885CYP3A4 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.