Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777246 | 0.91 | CTSK (0.49) | CTSSCTSKABCB1MMP13ATM | |
| SCHEMBL23205656 | 0.88 | S1PR3 (0.45) | CTSSCTSKABCB1MMP13ATM | |
| SCHEMBL12838215 | 0.86 | NPC1 (0.49) | CTSSCTSKABCB1MMP13MAPT | |
| SCHEMBL31477403 | 0.82 | CTSS (0.44) | CTSSCTSKABCB1MMP13ATM | |
| SCHEMBL6915011 | 0.81 | CYP3A4 (0.45) | CTSSCTSKMEN1KMT2AMMP13 | |
| SCHEMBL28588129 | 0.80 | CTSL (0.45) | CTSSCTSKABCB1MMP13ATM | |
| SCHEMBL12293491 | 0.80 | NAMPT (0.48) | CTSSCTSKABCB1ATMMAPT | |
| SCHEMBL10216722 | 0.78 | LMNA (0.44) | CTSSCTSKABCB1MEN1KMT2A | |
| SCHEMBL10217082 | 0.78 | ATM (0.43) | CTSSCTSKABCB1MMP13ATM | |
| SCHEMBL1542093 | 0.77 | ABCB1 (0.51) | CTSSCTSKABCB1MMP13ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486231-B2 | Targeted nitroxide compounds and their use in treating ferroptosis-related diseases | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2025-12-02 | — | — | US | disclosed |
| US-20220259149-A1 | Targeted Nitroxide Compounds and Their Use in Treating Ferroptosis-Related Diseases | DEFENSE THREAT REDUCTION AGENCY, US DOD | 2022-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486231-B2 | Targeted nitroxide compounds and their use in treating ferroptosis-related diseases | HMOX1, AIFM2, HMOX2 | CTSS 1785/4885CTSK 1410/4885ABCB1 2481/4885 |
| US-20220259149-A1 | Targeted Nitroxide Compounds and Their Use in Treating Ferroptosis-Related Diseases | HMOX1, AIFM2, HMOX2 | CTSS 1785/4885CTSK 1410/4885ABCB1 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.