Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.48 |
| ▸ | ACVR2A | P27037 | 3/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20609796 | 1.00 | NLRP3 (0.48) | NLRP3ACVR2ATGFBR2AAK1DYRK1A | |
| SCHEMBL20742969 | 0.88 | MAPK14 (0.42) | NLRP3ACVR2ATGFBR2MAPK13MAPK12 | |
| SCHEMBL20744375 | 0.88 | NLRP3 (0.41) | NLRP3ACVR2ATGFBR2AAK1MAPK13 | |
| SCHEMBL30684077 | 0.88 | NLRP3 (0.41) | NLRP3ACVR2ATGFBR2AAK1MAPK13 | |
| SCHEMBL30684129 | 0.88 | MAPK14 (0.42) | NLRP3ACVR2ATGFBR2MAPK13MAPK12 | |
| SCHEMBL22773957 | 0.87 | NLRP3 (0.48) | NLRP3ACVR2ATGFBR2AAK1DYRK1A | |
| SCHEMBL29467111 | 0.87 | NLRP3 (0.48) | NLRP3ACVR2ATGFBR2AAK1DYRK1A | |
| SCHEMBL22827688 | 0.86 | ACVR2A (0.43) | NLRP3ACVR2ATGFBR2AAK1DYRK1A | |
| SCHEMBL23385498 | 0.86 | NLRP3 (0.46) | NLRP3ACVR2ATGFBR2AAK1DYRK1A | |
| SCHEMBL30642351 | 0.86 | NLRP3 (0.46) | NLRP3ACVR2ATGFBR2AAK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250115618-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2025-04-10 | — | — | US | disclosed |
| US-20250109126-A1 | DIHYDRO-OXAZOL DERIVATIVE COMPOUNDS | AC IMMUNE SA (CH) | 2025-04-03 | — | — | US | disclosed |
| US-12234245-B2 | Sulfonimidamide compounds as inhibitors of interleukin-1 activity | GENENTECH, INC. (US) | 2025-02-25 | — | — | US | disclosed |
| EP-4452972-A1 | DIHYDRO-OXAZOL DERIVATIVE COMPOUNDS | AC Immune SA (CH) | 2024-10-30 | — | — | EP | disclosed |
| CN-118541366-A | Dihydrooxazole derivative compound | AC免疫有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-111132974-B | Sulfonamide carboxamide compounds | 英夫拉索姆有限公司 | 2023-11-21 | — | — | CN | disclosed |
| WO-2023118521-A1 | DIHYDRO-OXAZOL DERIVATIVE COMPOUNDS | AC IMMUNE SA (CH) | 2023-06-29 | — | — | WO | disclosed |
| US-11518739-B2 | Sulfonamide carboxamide compounds | INFLAZOME LIMITED (IE) | 2022-12-06 | — | — | US | disclosed |
| CN-114761383-A | Sulfonamide derivatives and uses thereof | 诺瑟拉有限公司 | 2022-07-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250115618-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | IL1A, IL18, IL1B | NLRP3 7/4885ACVR2A 4360/4885TGFBR2 4094/4885 |
| US-20250109126-A1 | DIHYDRO-OXAZOL DERIVATIVE COMPOUNDS | NLRP3, NLRP1, NOD1 | NLRP3 1/4885ACVR2A 3478/4885TGFBR2 1545/4885 |
| US-11518739-B2 | Sulfonamide carboxamide compounds | NLRP3, PYCARD, NOD1 | NLRP3 1/4885ACVR2A 4166/4885TGFBR2 3089/4885 |
| US-12234245-B2 | Sulfonimidamide compounds as inhibitors of interleukin-1 activity | IL1A, IL18, IL1B | NLRP3 7/4885ACVR2A 4360/4885TGFBR2 4094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.