SCHEMBL13560795

SCHEMBL13560795

COc1cc(-c2oc3cc(O)c(OC)c(O)c3c(=O)c2OC)ccc1O

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 5/20 0.86
TUBB P07437 5/20 0.86
TUBA3C P0DPH7 5/20 0.86
TUBA1B P68363 5/20 0.86
TUBA4A P68366 5/20 0.86
TUBB4B P68371 5/20 0.86
TUBB3 Q13509 5/20 0.86
TUBB2A Q13885 5/20 0.86
TUBB8 Q3ZCM7 5/20 0.86
TUBA3E Q6PEY2 5/20 0.86
TUBA1A Q71U36 5/20 0.86
TUBA1C Q9BQE3 5/20 0.86
TUBB6 Q9BUF5 5/20 0.86
TUBB2B Q9BVA1 5/20 0.86
TUBB1 Q9H4B7 5/20 0.86
NR0B1 P51843 1/20 0.82
XDH P47989 3/20 0.82
MAPT P10636 2/20 0.74
PKM P14618 1/20 0.74
ABCG2 Q9UNQ0 3/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29649084 1.00 TUBB4A (0.86) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Chrysosplenol B SCHEMBL29558792 0.93 ABCG2 (0.78) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL31589078 0.93 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29647956 0.93 TUBB4A (0.74) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Chrysosplenol B SCHEMBL2369883 0.93 ABCG2 (0.78) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL31589366 0.93 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL19461012 0.93 TUBB4A (0.74) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Chrysosplenol C SCHEMBL4742072 0.90 ABCG2 (0.73) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Centaureidin SCHEMBL9953 0.90 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Axillarin SCHEMBL29929599 0.90 XDH (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024046834-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS ANALYTICON DISCOVERY GMBH (DE) 2024-03-07 WO disclosed
EP-4331564-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS Analyticon Discovery GmbH (DE) 2024-03-06 EP disclosed
US-20230119060-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING, AS ACTIVE INGREDIENT, COMPLEX OF BIGUANIDE-BASED COMPOUND AND FLAVONE, HYDROXYFLAVONE, FLAVANONE, FLAVONE DERIVATIVE, HYDROXYFLAVONE DERIVATIVE, OR FLAVANONE DERIVATIVE MEDIENCE CO., LTD. (KR) 2023-04-20 US disclosed
US-10744114-B2 Use of eupatilin as pharmaceutical composition for prevention and treatment of fibrosis using EMT inhibitory activity OSTEONEUROGEN INC. (KR) 2020-08-18 US disclosed
US-10744113-B2 Use of chromone derivative as pharmaceutical composition for prevention and treatment of fibrosis using EMT inhibitory activity OSTEONEUROGEN INC. (KR) 2020-08-18 US disclosed
US-20190231739-A1 NEW USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY OSTEONEUROGEN INC. (KR) 2019-08-01 US disclosed
US-20170239211-A1 USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY OSTEONEUROGEN INC. (KR) 2017-08-24 US disclosed
US-8299119-B2 Biologically active compounds Bio-Active Export Pty. Ltd. (AU) 2012-10-30 US disclosed
US-8299119-B2 Biologically active compounds Bio-Active Export Pty. Ltd. (AU) 2012-10-30 US disclosed
US-20090221517-A1 Biologically Active Compounds BIO-ACTIVES EXPORT PTY., LTD. 2009-09-03 US disclosed
US-20090221517-A1 Biologically Active Compounds BIO-ACTIVES EXPORT PTY., LTD. 2009-09-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090221517-A1 Biologically Active Compounds MPO, CAT, CTSA TUBB4A 758/4885TUBB 765/4885TUBA3C 833/4885
US-20190231739-A1 NEW USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY CDH1, SMAD3, SMAD2 TUBB4A 1706/4885TUBB 1954/4885TUBA3C 2287/4885
US-10744113-B2 Use of chromone derivative as pharmaceutical composition for prevention and treatment of fibrosis using EMT inhibitory activity CDH1, SMAD3, SMAD2 TUBB4A 1634/4885TUBB 1881/4885TUBA3C 2103/4885
US-20230119060-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING, AS ACTIVE INGREDIENT, COMPLEX OF BIGUANIDE-BASED COMPOUND AND FLAVONE, HYDROXYFLAVONE, FLAVANONE, FLAVONE DERIVATIVE, HYDROXYFLAVONE DERIVATIVE, OR FLAVANONE DERIVATIVE SLC5A2, SLC5A1, SLC5A6 TUBB4A 4145/4885TUBB 4113/4885TUBA3C 3561/4885
US-20170239211-A1 USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY CDH1, SMAD3, SMAD2 TUBB4A 1634/4885TUBB 1881/4885TUBA3C 2103/4885
US-10744114-B2 Use of eupatilin as pharmaceutical composition for prevention and treatment of fibrosis using EMT inhibitory activity SMAD2, CDH1, SMAD3 TUBB4A 2023/4885TUBB 1687/4885TUBA3C 2262/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.