Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536384 | 1.00 | CRHBP (0.34) | CRHBPCRHR2MCOLN2KMT2ASMN1; SMN2 | |
| SCHEMBL23555092 | 0.88 | MCOLN2 (0.36) | MCOLN2KMT2ACXCR2KMOLMNA | |
| SCHEMBL29932095 | 0.88 | LMNA (0.40) | MCOLN2KMT2AALDH1A1LMNAGHSR | |
| SCHEMBL28867429 | 0.86 | MCOLN2 (0.34) | MCOLN2KMT2ACXCR2ALDH1A1KMO | |
| SCHEMBL29931826 | 0.86 | SLC22A12 (0.39) | KMT2ACXCR2ALDH1A1SLC40A1 | |
| SCHEMBL23536204 | 0.86 | ALDH1A1 (0.41) | MCOLN2KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23536479 | 0.86 | MCOLN2 (0.48) | MCOLN2KMT2AALDH1A1KMOLMNA | |
| SCHEMBL29932183 | 0.86 | ALDH1A1 (0.41) | MCOLN2KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23536230 | 0.84 | MCOLN2 (0.39) | MCOLN2KMT2ACXCR2ALDH1A1KMO | |
| SCHEMBL23555120 | 0.84 | MCOLN2 (0.37) | MCOLN2KMT2ACXCR2KMOGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |