Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.33 |
| ▸ | HTR2A | P28223 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932037 | 0.79 | MCOLN2 (0.37) | LMNAGAAHTT | |
| SCHEMBL23536699 | 0.75 | HTR6 (0.52) | DRD2 | |
| SCHEMBL29932225 | 0.73 | GAA (0.40) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23536404 | 0.73 | SLC18A3 (0.37) | PDE4BDRD2HTT | |
| SCHEMBL29931872 | 0.73 | SLC18A3 (0.37) | PDE4BDRD2HTT | |
| SCHEMBL23536524 | 0.66 | SMN1; SMN2 (0.36) | HTR2ALMNATP53GAAHTT | |
| SCHEMBL29948612 | 0.66 | LMNA (0.36) | HTR2AHTR1ADRD2HTR7LMNA | |
| SCHEMBL23536663 | 0.64 | HTR6 (0.46) | HTR2AHTR1ADRD2RORCLMNA | |
| SCHEMBL23555161 | 0.64 | SLC18A3 (0.38) | HTR1ATP53HTTHTR2C | |
| SCHEMBL19029431 | 0.64 | PDE4B (0.65) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |