Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536524 | 0.85 | SMN1; SMN2 (0.36) | HTR6LMNAGAATP53HTT | |
| SCHEMBL23536756 | 0.79 | LMNA (0.35) | HTR6LMNAGAATP53HTT | |
| SCHEMBL23536699 | 0.72 | HTR6 (0.52) | HTR6CYP3A4CYP2D6DRD2 | |
| SCHEMBL23536755 | 0.68 | CCR1 (0.43) | HTR6LMNAGAATP53HTT | |
| SCHEMBL23536607 | 0.67 | HTR6 (0.44) | HTR6LMNAHTTSMN1; SMN2CCR1 | |
| SCHEMBL23536676 | 0.66 | HTR6 (0.38) | HTR6LMNAGAATP53HTT | |
| SCHEMBL29932037 | 0.66 | MCOLN2 (0.37) | LMNAGAAHTTKDM4EALDH1A1 | |
| SCHEMBL26969694 | 0.65 | SMN1; SMN2 (0.44) | LMNAGAATP53HTTSMN1; SMN2 | |
| SCHEMBL23536654 | 0.65 | SCN5A (0.38) | HTR6LMNAGAATP53HTT | |
| SCHEMBL23536574 | 0.65 | SLC6A2 (0.40) | CCR1KCNH2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |