Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1199760 | 1.00 | TRPV4 (0.58) | TRPV4GAAFLT1FLT4KDR | |
| SCHEMBL2122763 | 0.84 | GAA (0.62) | TRPV4GAAFLT1FLT4KDR | |
| SCHEMBL251514 | 0.84 | GAA (0.62) | TRPV4GAAFLT1FLT4KDR | |
| SCHEMBL3932613 | 0.83 | TRPV4 (0.53) | TRPV4GAACDK1CCNB1CCNA2 | |
| SCHEMBL8405133 | 0.83 | L3MBTL1 (0.59) | TRPV4GAAFLT1FLT4KDR | |
| SCHEMBL31501416 | 0.81 | PDIA6 (0.51) | TRPV4GAAFLT1FLT4KDR | |
| SCHEMBL8296088 | 0.81 | PDIA6 (0.51) | TRPV4GAAFLT1FLT4KDR | |
| SCHEMBL4501445 | 0.81 | GAA (0.50) | TRPV4GAAFLT1FLT4KDR | |
| SCHEMBL11348441 | 0.80 | TRPV4 (0.41) | TRPV4GAACYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL692131 | 0.80 | ALDH1A1 (0.47) | TRPV4GAAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118903-A | Preparation method of trifluoroethyl sulfoxide substituted aryl compound and intermediate thereof | 陕西一简一至生物工程有限公司 | 2024-12-13 | — | — | CN | disclosed |
| EP-4061124-A1 | TRPV4 RECEPTOR LIGANDS | University of Utah Research Foundation (US) | 2022-09-28 | — | — | EP | disclosed |