Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 2/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | ALPI | P09923 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2546849 | 0.83 | CREBBP (0.69) | NOS1CREBBPALDH1A1KDM4ESMYD3 | |
| SCHEMBL349741 | 0.83 | CREBBP (0.65) | NOS1CREBBPALDH1A1KDM4ESMYD3 | |
| Chlorzoxazone SCHEMBL3004760 | 0.79 | NOS1 (0.59) | PARP1NOS1KDM4ENOS3NOS2 | |
| SCHEMBL12798 | 0.72 | PARP1 (1.00) | PARP1POLBTDP1MEN1KMT2A | |
| SCHEMBL13799999 | 0.72 | PARP1 (1.00) | PARP1POLBTDP1MEN1KMT2A | |
| SCHEMBL14333454 | 0.72 | NOS1 (0.54) | PARP1NOS1CREBBPALDH1A1KDM4E | |
| SCHEMBL1119326 | 0.72 | NOS1 (0.59) | NOS1CREBBPALDH1A1KDM4ESMYD3 | |
| SCHEMBL8698103 | 0.71 | PSMB8 (0.59) | PARP1NOS1CREBBPALDH1A1KDM4E | |
| SCHEMBL244119 | 0.71 | NOS1 (1.00) | NOS1CREBBPALDH1A1KDM4ENOS3 | |
| SCHEMBL6647933 | 0.71 | ALDH1A1 (0.60) | NOS1CREBBPALDH1A1KDM4ESMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173961-A1 | BENZOOXAZOL-2-ONE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | US | disclosed |
| US-7709513-B2 | Benzooxazol-2-one derivatives as lipase and phospholipase inhibitors | SANOFI-AVENTIS (FR) | 2010-05-04 | — | — | US | disclosed |
| US-20080167355-A1 | BENZOOXAZOL-2-ONE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI-AVENTIS (FR) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167355-A1 | BENZOOXAZOL-2-ONE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | CEL, PNLIP, LPL | PARP1 1530/4885NOS1 1305/4885CREBBP 1399/4885 |
| US-20100173961-A1 | BENZOOXAZOL-2-ONE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | CEL, PNLIP, LPL | PARP1 1530/4885NOS1 1305/4885CREBBP 1399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.