Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | APOL1 | O14791 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3009135 | 0.84 | POLB (0.41) | CYP3A4CYP2C19SMN1; SMN2HPGDLMNA | |
| SCHEMBL2998347 | 0.81 | CYP3A4 (0.43) | CYP3A4CYP2C19SMN1; SMN2HPGDLMNA | |
| SCHEMBL3000934 | 0.79 | EPHX1 (0.47) | CYP3A4CYP2C19SMN1; SMN2HPGDLMNA | |
| SCHEMBL13448190 | 0.79 | ALDH1A1 (0.36) | CYP3A4CYP2C19SMN1; SMN2HTTHPGD | |
| SCHEMBL12605674 | 0.78 | SMN1; SMN2 (0.45) | CYP3A4CYP2C19SMN1; SMN2HTTHPGD | |
| SCHEMBL3000839 | 0.76 | MME (0.42) | LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL27886475 | 0.76 | SMN1; SMN2 (0.47) | CYP3A4CYP2C19SMN1; SMN2HTTHPGD | |
| SCHEMBL2998922 | 0.72 | NSD2 (0.32) | CYP3A4SMN1; SMN2 | |
| SCHEMBL15252887 | 0.71 | MME (0.38) | LMNAALDH1A1MAPT | |
| SCHEMBL23792668 | 0.68 | EPHX2 (0.41) | CYP3A4CYP2C19SMN1; SMN2HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168567-B1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | ORÉAL L (FR) | 2015-12-16 | — | — | EP | claimed |
| US-8617524-B2 | Depigmenting keratin materials utilizing dithiolane compounds | L'OREAL (FR) | 2013-12-31 | — | — | US | claimed |
| EP-2191816-B1 | Depigmentation of keratinic material using specific dithiolanes | OREAL (FR) | 2013-09-18 | — | — | EP | claimed |
| US-8535647-B2 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2013-09-17 | — | — | US | claimed |
| US-8530511-B2 | Administration of dithiolane compounds for photoprotecting the skin | L'OREAL (FR) | 2013-09-10 | — | — | US | claimed |
| EP-2174644-B1 | Cosmetic composition comprising a dibenzoylmethane derivative and a dithiolane; Photostabilization of a dibenzoylmethane derivative | OREAL (FR) | 2012-11-14 | — | — | EP | claimed |
| US-20100197759-A1 | Administration of dithiolane compounds for photoprotecting the skin | L'OREAL (FR) | 2010-08-05 | — | — | US | claimed |
| US-20100135942-A1 | Depigmenting keratin materials utilizing dithiolane compounds | L'OREAL (FR) | 2010-06-03 | — | — | US | claimed |
| EP-2191816-A1 | Depigmentation of keratinic material using specific dithiolanes | L'OREAL (FR) | 2010-06-02 | — | — | EP | claimed |
| EP-2174644-A1 | Cosmetic composition comprising a dibenzoylmethane derivative and a dithiolane; Photostabilization of a dibenzoylmethane derivative | L'OREAL (FR) | 2010-04-14 | — | — | EP | claimed |
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2010-04-08 | — | — | US | claimed |
| EP-2168567-A1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | L'Oréal (FR) | 2010-03-31 | — | — | EP | claimed |
| EP-2168567-B1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | ORÉAL L (FR) | 2015-12-16 | — | — | EP | disclosed |
| EP-2168567-B1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | ORÉAL L (FR) | 2015-12-16 | — | — | EP | disclosed |
| US-8617524-B2 | Depigmenting keratin materials utilizing dithiolane compounds | L'OREAL (FR) | 2013-12-31 | — | — | US | disclosed |
| EP-2191816-B1 | Depigmentation of keratinic material using specific dithiolanes | OREAL (FR) | 2013-09-18 | — | — | EP | disclosed |
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2010-04-08 | — | — | US | disclosed |
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2010-04-08 | — | — | US | disclosed |
| EP-2168567-A1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | L'Oréal (FR) | 2010-03-31 | — | — | EP | disclosed |
| EP-2168567-A1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | L'Oréal (FR) | 2010-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | NOTUM, DDT, FDFT1 | CYP3A4 1363/4885CYP2C19 1161/4885SMN1; SMN2 4821/4885 |
| US-20100197759-A1 | Administration of dithiolane compounds for photoprotecting the skin | GPX1, GPX4, TXN | CYP3A4 2913/4885CYP2C19 2226/4885SMN1; SMN2 4859/4885 |
| US-20100135942-A1 | Depigmenting keratin materials utilizing dithiolane compounds | KRT18, NR1D1, RER1 | CYP3A4 1905/4885CYP2C19 1598/4885SMN1; SMN2 4718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.