Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 12/20 | 0.47 |
| ▸ | PPARD | Q03181 | 15/20 | 0.47 |
| ▸ | PPARA | Q07869 | 14/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513353 | 0.91 | PPARD (0.57) | PPARDPPARAPPARG | |
| SCHEMBL30007652 | 0.79 | PPARD (0.56) | PPARDPPARAPPARG | |
| SCHEMBL3511782 | 0.78 | PPARD (0.54) | PPARDPPARAPPARG | |
| SCHEMBL30007517 | 0.77 | PPARA (0.55) | PPARDPPARAPPARG | |
| SCHEMBL3509000 | 0.76 | PPARD (0.49) | PPARDPPARAPPARG | |
| SCHEMBL3512170 | 0.74 | PPARD (0.46) | PPARDPPARAPPARG | |
| SCHEMBL1935430 | 0.69 | PPARA (0.55) | PPARDPPARAPPARG | |
| SCHEMBL3512485 | 0.68 | PPARD (0.45) | PPARDPPARAPPARG | |
| SCHEMBL2153233 | 0.67 | PPARA (0.45) | PPARDPPARAPPARG | |
| SCHEMBL3510967 | 0.67 | PPARA (0.51) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337184-A1 | PPAR-AGONISTS FOR USE IN THE TREATMENT OF LIVER FAILURE | Genfit (FR) | 2024-03-20 | — | — | EP | disclosed |
| EP-4337185-A1 | ELAFIBRANOR DERIVATIVES AGONISTS OF PPAR FOR USE IN THE TREATMENT OF SEPSIS | Genfit (FR) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022238445-A1 | PPAR-AGONISTS FOR USE IN THE TREATMENT OF LIVER FAILURE | GENFIT (FR) | 2022-11-17 | — | — | WO | disclosed |
| WO-2022238448-A1 | ELAFIBRANOR DERIVATIVES AGONISTS OF PPAR FOR USE IN THE TREATMENT OF SEPSIS | GENFIT (FR) | 2022-11-17 | — | — | WO | disclosed |