Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 9/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27141895 | 1.00 | MGLL (0.38) | MGLLHSD11B1MAPK7SOS1SLC6A4 | |
| SCHEMBL27148092 | 0.93 | MGLL (0.38) | MGLLHSD11B1MAPK7SOS1SLC6A4 | |
| SCHEMBL30014591 | 0.93 | MGLL (0.38) | MGLLHSD11B1MAPK7SOS1SLC6A4 | |
| SCHEMBL28891876 | 0.91 | NR3C1 (0.38) | MGLLSOS1SLC6A4 | |
| SCHEMBL27137196 | 0.90 | GPR119 (0.39) | — | |
| SCHEMBL31024363 | 0.90 | GPR119 (0.39) | — | |
| SCHEMBL27137184 | 0.89 | HSD11B1 (0.35) | MGLLHSD11B1PDE4B | |
| SCHEMBL29281606 | 0.87 | DDB1 (0.38) | MGLL | |
| SCHEMBL29201746 | 0.87 | MGLL (0.39) | MGLLHSD11B1 | |
| SCHEMBL27137025 | 0.84 | RBP4 (0.38) | MGLLHSD11B1SOS1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022223034-A1 | SOS1 DEGRADATION AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223033-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223039-A1 | SOS1 DEGRADER, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |