Resomelagon

Resomelagon

SCHEMBL30065346

O=CO.[H]/N=C(\N)NN=CC=Cc1cccn1-c1ccccc1[N+](=O)[O-]

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.40
▸ MAPT P10636 8/20 0.39
▸ SMN1; SMN2 Q16637 4/20 0.39
▸ GAA P10253 3/20 0.39
▸ RAB9A P51151 6/20 0.38
▸ NPC1 O15118 5/20 0.38
▸ ALDH1A1 P00352 9/20 0.38
▸ MEN1 O00255 3/20 0.38
▸ PKM P14618 1/20 0.38
▸ LMNA P02545 4/20 0.36
▸ HTT P42858 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ ATM Q13315 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Resomelagon SCHEMBL30084719 0.97 MAPT (0.41) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL30853069 0.95 MAPT (0.40) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL31103565 0.93 RAB9A (0.41) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL30010038 0.93 RAB9A (0.41) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL28929656 0.93 RAB9A (0.41) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL30853078 0.91 NPC1 (0.42) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL31103411 0.91 ALDH1A1 (0.46) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL30853077 0.91 NPC1 (0.42) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL30064265 0.90 RAB9A (0.39) KMT2AMAPTSMN1; SMN2GAARAB9A
Resomelagon SCHEMBL30065112 0.90 RAB9A (0.39) KMT2AMAPTSMN1; SMN2GAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4684835-A2 PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS SynAct Pharma ApS (DK) 2026-01-28 — — EP claimed
EP-4359076-A1 PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS SynAct Pharma ApS (DK) 2024-05-01 — — EP claimed
CN-117642382-A Phenylpyrrole aminoguanidine salts and formulations 西奈克制药有限公司 2024-03-01 — — CN claimed
WO-2022268825-A1 PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS SYNACT PHARMA APS (DK) 2022-12-29 — — WO claimed
EP-4684835-A2 PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS SynAct Pharma ApS (DK) 2026-01-28 — — EP disclosed
WO-2025124760-A1 TREATMENT OF SUBPOPULATION OF PATIENTS WITH RHEUMATOID ARTHRITIS SYNACT PHARMA APS (DK) 2025-06-19 — — WO disclosed
US-12239631-B2 Polymorphs of phenyl pyrrole aminoguandium salts SYNACT PHARMA APS (DK) 2025-03-04 — — US disclosed
US-20250032449-A1 TREATMENT OF RHEUMATOID ARTHRITIS SYNACT PHARMA APS (DK) 2025-01-30 — — US disclosed
US-20240335423-A1 POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS SYNACT PHARMA APS (DK) 2024-10-10 — — US disclosed
EP-4440572-A1 TREATMENT OF RHEUMATOID ARTHRITIS SynAct Pharma ApS (DK) 2024-10-09 — — EP disclosed
CN-118613260-A Treatment of rheumatoid arthritis 西奈克制药有限公司 2024-09-06 — — CN disclosed
EP-4359383-A1 SALTS OF PHENYL PYRROLE AMINOGUANIDINE AND POLYMORPHS OF PHENYL PYRROLE AMINOGUANIDINIUM SALTS SynAct Pharma ApS (DK) 2024-05-01 — — EP disclosed
CN-117836271-A Salts of phenylpyrrolaminoguanidine and polymorphs of phenylpyrrolaminoguanidine onium salts 西奈克制药有限公司 2024-04-05 — — CN disclosed
CN-117642382-A Phenylpyrrole aminoguanidine salts and formulations 西奈克制药有限公司 2024-03-01 — — CN disclosed
US-20230271922-A9 POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS SYNACT PHARMA APS (DK) 2023-08-31 — — US disclosed
WO-2023094692-A1 TREATMENT OF RHEUMATOID ARTHRITIS SYNACT PHARMA APS (DK) 2023-06-01 — — WO disclosed
US-20230114865-A1 PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS SYNACT PHARMA APS (DK) 2023-04-13 — — US disclosed
US-20230002319-A1 POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS SYNACT PHARMA APS (DK) 2023-01-05 — — US disclosed
WO-2022268825-A1 PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS SYNACT PHARMA APS (DK) 2022-12-29 — — WO disclosed
WO-2022268814-A1 SALTS OF PHENYL PYRROLE AMINOGUANIDINE AND POLYMORPHS OF PHENYL PYRROLE AMINOGUANIDINIUM SALTS SYNACT PHARMA APS (DK) 2022-12-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250032449-A1 TREATMENT OF RHEUMATOID ARTHRITIS MTX1, MTX2, SYVN1 KMT2A 3306/4885MAPT 2711/4885SMN1; SMN2 3457/4885
US-20230114865-A1 PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS AAAS, PGC, DNPEP KMT2A 2093/4885MAPT 1206/4885SMN1; SMN2 1113/4885
US-20230271922-A9 POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS HLA-C, HLA-DRB1, HLA-B KMT2A 4584/4885MAPT 481/4885SMN1; SMN2 2263/4885
US-12239631-B2 Polymorphs of phenyl pyrrole aminoguandium salts HLA-C, HLA-DRB1, HLA-B KMT2A 4584/4885MAPT 481/4885SMN1; SMN2 2263/4885
US-20230002319-A1 POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS HLA-C, HLA-DRB1, HLA-B KMT2A 4584/4885MAPT 481/4885SMN1; SMN2 2263/4885
US-20240335423-A1 POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS HLA-C, HLA-DRB1, HLA-B KMT2A 4584/4885MAPT 481/4885SMN1; SMN2 2263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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