Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 9/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.39 |
| ▸ | RET | P07949 | 9/20 | 0.39 |
| ▸ | ROS1 | P08922 | 9/20 | 0.39 |
| ▸ | FLT3 | P36888 | 9/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30299305 | 0.92 | ALDH1A1 (0.38) | — | |
| SCHEMBL30090486 | 0.89 | KCNH2 (0.39) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30299385 | 0.80 | KCNH2 (0.37) | ALKFGFR3KCNH2ACVR1 | |
| SCHEMBL30299323 | 0.80 | NPY2R (0.41) | — | |
| SCHEMBL29929683 | 0.79 | AXL (0.40) | EGFR | |
| SCHEMBL30299368 | 0.79 | GAA (0.38) | KCNH2 | |
| SCHEMBL29928123 | 0.78 | AXL (0.39) | EGFR | |
| SCHEMBL30299390 | 0.78 | PDCD1 (0.38) | ALKKCNH2 | |
| SCHEMBL30299371 | 0.77 | ALDH1A1 (0.43) | FLT3 | |
| SCHEMBL30299369 | 0.77 | AXL (0.37) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075303-A | Method of selecting patients treated with a combination of an AXL inhibitor and an immune checkpoint modulator | 卑尔根生物股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-115916344-A | AXL inhibitors for antiviral therapy | 卑尔根生物股份公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115414480-A | Dianhydrogalactitol in combination with radiation for treatment of non-small cell lung cancer and glioblastoma multiforme | 德玛医药 | 2022-12-02 | — | — | CN | disclosed |