SCHEMBL30104898

SCHEMBL30104898

COC1OC(=O)C(Cl)=C1SCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 1/20 0.41
ALDH1A1 P00352 5/20 0.39
HTT P42858 5/20 0.39
HPGD P15428 3/20 0.39
MAPT P10636 5/20 0.38
NPSR1 Q6W5P4 4/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
PKM P14618 3/20 0.37
GAA P10253 2/20 0.37
S100A4 P26447 1/20 0.37
LMNA P02545 3/20 0.36
PPARG P37231 2/20 0.36
NCOA2 Q15596 2/20 0.36
NCOA1 Q15788 2/20 0.36
KDM4E B2RXH2 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ELANE P08246 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30104867 0.86 MAPK1 (0.47) CCKBRALDH1A1HTTHPGDMAPT
SCHEMBL30104899 0.84 CCKBR (0.38) CCKBRALDH1A1HTTHPGDMAPT
SCHEMBL30104902 0.83 S100A4 (0.37) ALDH1A1HTTHPGDMAPTPKM
SCHEMBL30104880 0.74 NUAK1 (0.35) CCKBRALDH1A1HTTMAPTKDM4E
SCHEMBL30104874 0.71 CCKBR (0.59) CCKBRALDH1A1MAPTCYP2C19LMNA
SCHEMBL30104840 0.69 NR2E3 (0.37) CCKBRALDH1A1HTTMAPTS100A4
SCHEMBL30104872 0.69 POLB (0.38) CCKBRALDH1A1HPGDS100A4LMNA
SCHEMBL30104893 0.68 CCKBR (0.41) CCKBRALDH1A1S100A4LMNASMN1; SMN2
SCHEMBL14505730 0.65 KDM4E (0.40) CCKBRALDH1A1HTTMAPTGAA
SCHEMBL6153909 0.65 CCKBR (0.59) CCKBRALDH1A1MAPTCYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115583927-B Thioether compound, and preparation method and application thereof 华南师范大学 2024-07-12 CN disclosed
CN-115583927-A Thioether compound and preparation method and application thereof 华南师范大学 2023-01-10 CN disclosed