Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.38 |
| ▸ | TUBB | P07437 | 2/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 2/20 | 0.35 |
| ▸ | LDHB | P07195 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014352 | 0.88 | RHEB (0.45) | RHEBPTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL6482406 | 0.75 | PTGS2 (0.45) | RHEBPTGS2TYMSDHFRHAO1 | |
| SCHEMBL5359403 | 0.74 | IDO1 (0.42) | RHEBPTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL3000123 | 0.71 | RHEB (0.42) | RHEBPTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL3012434 | 0.70 | ENPP2 (0.54) | RHEBPTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL5355744 | 0.70 | IDO1 (0.56) | RHEBPTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL5348378 | 0.70 | AKR1B1 (0.46) | RHEBPTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL1251770 | 0.70 | PTGS2 (0.52) | PTGS2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL26165602 | 0.69 | DHFR (0.49) | RHEBLDHALDHBDHFRHAO1 | |
| SCHEMBL22609023 | 0.68 | AHR (0.52) | FEN1AHRMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178764-A1 | Novel Compounds | BONNERT ROGER (GB) | 2012-07-12 | — | — | US | disclosed |
| US-20100197756-A1 | Indole-3-Sulphur Derivatives | ASTRAZENECA AB (SE) | 2010-08-05 | — | — | US | disclosed |
| US-7723373-B2 | Indole-3-sulphur derivatives | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| US-7687535-B2 | Substituted 3-sulfur indoles | ASTRAZENECA AB (SE) | 2010-03-30 | — | — | US | disclosed |
| EP-1551802-B1 | INDOLE-3-SULPHUR DERIVATIVES | ASTRAZENECA AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| US-20090163518-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2009-06-25 | — | — | US | disclosed |
| EP-2025670-A1 | 3-(Phenyl or quinolyl)thio-1H-indole-1-acetic acid derivatives as modulators of CRTh2 receptor activity | AstraZeneca AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| US-20080249110-A1 | Novel Substituted 3-Sulfur Indoles | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | US | disclosed |
| US-7166607-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2007-01-23 | — | — | US | disclosed |
| US-20060111426-A1 | Indole-3-sulphur derivaties | ASTRAZENECA AB (SE) | 2006-05-25 | — | — | US | disclosed |
| US-20050165055-A1 | Novel substituted indoles | ASTRAZENECA AB (SE) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165055-A1 | Novel substituted indoles | IDO1, IDO2, TPH1 | RHEB 2834/4885PTGS2 539/4885TUBB4A 1248/4885 |
| US-20100197756-A1 | Indole-3-Sulphur Derivatives | IDO1, IDO2, INMT | RHEB 2326/4885PTGS2 534/4885TUBB4A 1833/4885 |
| US-20120178764-A1 | Novel Compounds | IDO1, IDO2, MTNR1A | RHEB 1592/4885PTGS2 339/4885TUBB4A 1744/4885 |
| US-20090163518-A1 | Novel Compounds | IDO1, IDO2, MTNR1A | RHEB 1592/4885PTGS2 339/4885TUBB4A 1744/4885 |
| US-20060111426-A1 | Indole-3-sulphur derivaties | IDO1, IDO2, INMT | RHEB 3112/4885PTGS2 853/4885TUBB4A 2511/4885 |
| US-20080249110-A1 | Novel Substituted 3-Sulfur Indoles | IDO1, IDO2, AANAT | RHEB 3148/4885PTGS2 926/4885TUBB4A 1582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.