Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938291 | 0.80 | MAP2 (0.55) | BCAT1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3017326 | 0.72 | AKR1B1 (0.47) | PTGS2GAAHPGDMEN1KMT2A | |
| SCHEMBL3478192 | 0.69 | TUBB4A (0.48) | PTGS2LMNAGAAHPGDCSF1R | |
| SCHEMBL2062055 | 0.67 | LMNA (0.57) | PTGS2LMNACYP1A2GAAHPGD | |
| SCHEMBL30547019 | 0.67 | LMNA (0.56) | LMNACYP1A2GAAHPGDTUBB4A | |
| SCHEMBL9843379 | 0.67 | LMNA (0.56) | LMNACYP1A2GAAHPGDTUBB4A | |
| SCHEMBL5355744 | 0.67 | IDO1 (0.56) | PTGS2LMNACYP1A2GAAHPGD | |
| SCHEMBL3477191 | 0.67 | FFAR2 (0.60) | PTGS2CSF1RTUBB4ATUBBTUBA3C | |
| SCHEMBL10720773 | 0.67 | LMNA (0.56) | LMNACYP1A2GAAHPGDKMT2A | |
| SCHEMBL28145723 | 0.67 | ADRA2A (0.51) | PTGS2LMNACYP1A2GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197756-A1 | Indole-3-Sulphur Derivatives | ASTRAZENECA AB (SE) | 2010-08-05 | — | — | US | disclosed |
| US-7723373-B2 | Indole-3-sulphur derivatives | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| EP-1551802-B1 | INDOLE-3-SULPHUR DERIVATIVES | ASTRAZENECA AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| US-20060111426-A1 | Indole-3-sulphur derivaties | ASTRAZENECA AB (SE) | 2006-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197756-A1 | Indole-3-Sulphur Derivatives | IDO1, IDO2, INMT | PTGS2 534/4885LMNA 4648/4885CYP1A2 1063/4885 |
| US-20060111426-A1 | Indole-3-sulphur derivaties | IDO1, IDO2, INMT | PTGS2 853/4885LMNA 4699/4885CYP1A2 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.