Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477961 | 0.82 | KMT2A (0.49) | AKR1B1PTGDR2POLBDUSP3PTPN5 | |
| SCHEMBL4612168 | 0.80 | EGFR (0.47) | PTGS2KMT2AMEN1EGFRSRC | |
| SCHEMBL3010277 | 0.77 | ALDH1A1 (0.44) | PTGDR2POLBPTGS2KMT2AMEN1 | |
| SCHEMBL7477659 | 0.77 | ALDH1A1 (0.51) | PTGS2KMT2AMEN1EGFRSRC | |
| SCHEMBL8126205 | 0.76 | TUBB4A (0.48) | AKR1B1PTGDR2POLBKMT2AMEN1 | |
| SCHEMBL11336102 | 0.75 | ALDH1A1 (0.50) | POLBPTGS2KMT2AMEN1ALDH1A1 | |
| SCHEMBL3012967 | 0.72 | PTGS2 (0.46) | PTGDR2POLBDUSP3PTPN5PTPN11 | |
| SCHEMBL3010919 | 0.71 | ALDH1A1 (0.43) | AKR1B1PTGDR2PTGS2KMT2AMEN1 | |
| SCHEMBL4543167 | 0.71 | KDM4E (0.52) | POLBDUSP3PTPN5PTPN11ALDH1A1 | |
| SCHEMBL3476947 | 0.71 | HTR1A (0.47) | POLBDUSP3PTPN5PTPN11PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197756-A1 | Indole-3-Sulphur Derivatives | ASTRAZENECA AB (SE) | 2010-08-05 | — | — | US | disclosed |
| US-7723373-B2 | Indole-3-sulphur derivatives | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| EP-1551802-B1 | INDOLE-3-SULPHUR DERIVATIVES | ASTRAZENECA AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| US-20060111426-A1 | Indole-3-sulphur derivaties | ASTRAZENECA AB (SE) | 2006-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197756-A1 | Indole-3-Sulphur Derivatives | IDO1, IDO2, INMT | AKR1B1 1827/4885PTGDR2 525/4885POLB 4688/4885 |
| US-20060111426-A1 | Indole-3-sulphur derivaties | IDO1, IDO2, INMT | AKR1B1 860/4885PTGDR2 674/4885POLB 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.