Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29218170 | 0.79 | FGFR1 (0.53) | FGFR1MAPTKDM4ENPC1RAB9A | |
| SCHEMBL30163022 | 0.74 | NPC1 (0.42) | FGFR1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL2677079 | 0.70 | PDE5A (0.44) | KDM4ENPSR1ATMKMT2AADORA3 | |
| SCHEMBL14255124 | 0.69 | CDC7 (0.43) | FGFR1MAPTATMALDH1A1 | |
| SCHEMBL28287916 | 0.68 | MAPT (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30999883 | 0.66 | FGFR1 (0.50) | FGFR1MAPTNPC1RAB9AIDO1 | |
| SCHEMBL14333535 | 0.65 | ADORA3 (0.43) | MAPTKDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL5700377 | 0.65 | GABRA1 (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL16259059 | 0.65 | SCN9A (0.38) | NPC1RAB9AKMT2AALDH1A1GAA | |
| SCHEMBL29366393 | 0.65 | ALDH1A1 (0.51) | FGFR1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |