Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ESRRB | O95718 | 3/20 | 0.39 |
| ▸ | ESRRA | P11474 | 3/20 | 0.39 |
| ▸ | ESRRG | P62508 | 3/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21876915 | 0.88 | SLC6A2 (0.49) | CACNA2D1CACNA1BCACNB1SLC6A2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL29198405 | 0.82 | CACNA2D1 (0.41) | CACNA2D1CACNA1BCACNB1SLC6A2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL29198403 | 0.82 | CRBN (0.41) | CACNA2D1CACNA1BCACNB1DRD2DRD4 | |
| SCHEMBL27160034 | 0.78 | SLC6A2 (0.55) | SLC6A2SLC6A4DRD2DRD4FPR2 | |
| SCHEMBL21876572 | 0.77 | SLC6A2 (0.46) | SLC6A2SLC6A4THRBESRRBESRRA | |
| Trifluoroacetic Acid SCHEMBL8126751 | 0.77 | ADRB2 (0.48) | ALDH1A1 | |
| SCHEMBL27366886 | 0.74 | LTA4H (0.49) | CACNA2D1CACNA1BCACNB1DRD2DRD4 | |
| SCHEMBL27367743 | 0.74 | ADRB1 (0.57) | CACNA2D1CACNA1BCACNB1DRD2DRD4 | |
| SCHEMBL20046403 | 0.74 | GPR119 (0.43) | CACNA2D1CACNA1BCACNB1DRD2MAPT | |
| Trifluoroacetic Acid SCHEMBL30349693 | 0.73 | OPRM1 (0.48) | CACNA2D1CACNA1BCACNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260115296-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | UNIV YALE (US) | 2026-04-30 | — | — | US | disclosed |
| US-20230000994-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | YALE UNIVERSITY | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230000994-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | CRBN, ARAF, VHL | CACNA2D1 4708/4885CACNA1B 4819/4885CACNB1 4068/4885 |
| US-20260115296-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | CRBN, VHL, ADRM1 | CACNA2D1 4560/4885CACNA1B 4769/4885CACNB1 3762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.