SCHEMBL30199348

SCHEMBL30199348

COc1ccc2c(c1)[nH]c1c(C(N)=O)nccc12

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 12/20 0.79
ACHE P22303 2/20 0.79
BCHE P06276 2/20 0.79
CLK1 P49759 3/20 0.64
CDK5 Q00535 3/20 0.64
CDK5R1 Q15078 3/20 0.64
GSK3B P49841 2/20 0.64
MAOA P21397 2/20 0.64
KDM4E B2RXH2 1/20 0.64
DYRK3 O43781 1/20 0.64
CCNT1 O60563 1/20 0.64
CCNB2 O95067 1/20 0.64
ALDH1A1 P00352 1/20 0.64
CYP1A2 P05177 1/20 0.64
CDK1 P06493 1/20 0.64
CYP3A4 P08684 1/20 0.64
ADRA2A P08913 1/20 0.64
CYP2D6 P10635 1/20 0.64
CCNB1 P14635 1/20 0.64
HPGD P15428 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25832011 1.00 DYRK1A (0.79) DYRK1AACHEBCHECLK1CDK5
SCHEMBL25832010 0.88 DYRK1A (0.81) DYRK1AACHEBCHECLK1CDK5
SCHEMBL30601059 0.88 DYRK1A (0.81) DYRK1AACHEBCHECLK1CDK5
Arenarine C SCHEMBL30199121 0.88 DYRK1A (1.00) DYRK1AACHEBCHECLK1CDK5
Arenarine C SCHEMBL645800 0.88 DYRK1A (1.00) DYRK1AACHEBCHECLK1CDK5
Harmic Acid Methyl Ester SCHEMBL25294090 0.87 DYRK1A (0.79) DYRK1AACHEBCHECLK1CDK5
Trigonostemine B SCHEMBL30492900 0.81 DYRK1A (0.69) DYRK1AACHEBCHECLK1CDK5
SCHEMBL23150327 0.80 DYRK1A (0.72) DYRK1AACHEBCHECLK1CDK5
SCHEMBL31546623 0.79 DYRK1A (0.57) DYRK1AACHEBCHECLK1CDK5
Harmine SCHEMBL292955 0.78 MAOA (1.00) DYRK1AACHEBCHECLK1CDK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2926119-B1 METHOD OF MARKING OF MATERIAL, MARKED MATERIAL AND METHOD FOR AUTHENTICATING A MATERIAL SICPA HOLDING SA (CH) 2023-02-22 EP claimed
US-20250171749-A1 GENETICALLY MODIFIED ORGANISMS FOR PRODUCING PSYCHOTROPIC ALKALOIDS Empyrean Neuroscience, Inc. 2025-05-29 US disclosed
CN-118984868-A Genetically modified organisms for the production of psychotropic alkaloids 恩派瑞安神经科学公司 2024-11-19 CN disclosed
EP-4457336-A2 GENETICALLY MODIFIED ORGANISMS FOR PRODUCING PSYCHOTROPIC ALKALOIDS Empyrean Neuroscience, Inc. (US) 2024-11-06 EP disclosed
US-12104179-B2 Genetically modified organisms for producing psychotropic alkaloids Empyrean Neuroscience, Inc. (US) 2024-10-01 US disclosed
US-20240101976-A1 GENETICALLY MODIFIED ORGANISMS FOR PRODUCING PSYCHOTROPIC ALKALOIDS Empyrean Neuroscience, Inc. 2024-03-28 US disclosed
WO-2023130076-A2 TARGETS AND PATHWAYS FOR THE PRODUCTION OF ALKALOIDAL COMPOUNDS Empyrean Neuroscience, Inc. (US) 2023-07-06 WO disclosed
WO-2023130078-A2 GENETICALLY MODIFIED MYCELIUM FOR PRODUCING PSYCHOTROPIC ALKALOIDS Empyrean Neuroscience, Inc. (US) 2023-07-06 WO disclosed
WO-2023130075-A2 GENETICALLY MODIFIED ORGANISMS FOR PRODUCING PSYCHOTROPIC ALKALOIDS Empyrean Neuroscience, Inc. (US) 2023-07-06 WO disclosed
EP-2926119-B1 METHOD OF MARKING OF MATERIAL, MARKED MATERIAL AND METHOD FOR AUTHENTICATING A MATERIAL SICPA HOLDING SA (CH) 2023-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250171749-A1 GENETICALLY MODIFIED ORGANISMS FOR PRODUCING PSYCHOTROPIC ALKALOIDS PNMT, INMT, AANAT DYRK1A 569/4885ACHE 81/4885BCHE 31/4885
US-20240101976-A1 GENETICALLY MODIFIED ORGANISMS FOR PRODUCING PSYCHOTROPIC ALKALOIDS PNMT, INMT, AANAT DYRK1A 569/4885ACHE 81/4885BCHE 31/4885
US-12104179-B2 Genetically modified organisms for producing psychotropic alkaloids PNMT, INMT, AANAT DYRK1A 569/4885ACHE 81/4885BCHE 31/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.