Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30201287 | 0.88 | MTNR1A (0.56) | MTNR1AMTNR1BRAB9AALDH1A1NPC1 | |
| SCHEMBL30201055 | 0.88 | ALDH1A1 (0.47) | MTNR1AMTNR1BRAB9ALMNAALDH1A1 | |
| SCHEMBL30201012 | 0.85 | MTNR1B (0.55) | MTNR1AMTNR1BRAB9ALMNAL3MBTL1 | |
| SCHEMBL30201095 | 0.84 | MTNR1A (0.52) | MTNR1AMTNR1BLMNAALDH1A1MEN1 | |
| Formic Acid SCHEMBL30201032 | 0.83 | ALDH1A1 (0.46) | MTNR1AMTNR1BRAB9ALMNAALDH1A1 | |
| SCHEMBL30201025 | 0.79 | ALDH1A1 (0.44) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL30201393 | 0.77 | MTNR1A (0.48) | MTNR1AMTNR1B | |
| SCHEMBL30201042 | 0.77 | MTNR1A (0.56) | MTNR1AMTNR1BRAB9ALMNAALDH1A1 | |
| SCHEMBL30200758 | 0.76 | MTNR1A (0.47) | MTNR1AMTNR1BLMNAALDH1A1L3MBTL1 | |
| SCHEMBL30200979 | 0.76 | MTNR1A (0.47) | MTNR1AMTNR1BALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023028086-A1 | COMBINATIONS OF PERIPHERAL 5-HT2A RECEPTOR ANTAGONISTS AND CENTRAL 5-HT2A RECEPTOR AGONISTS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |