Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30201287 | 0.85 | MTNR1A (0.56) | MTNR1AMTNR1BSMN1; SMN2GAAMAPT | |
| SCHEMBL30200879 | 0.84 | MTNR1A (0.55) | MTNR1AMTNR1BSMN1; SMN2LMNAMEN1 | |
| SCHEMBL30201012 | 0.82 | MTNR1B (0.55) | MTNR1AMTNR1BSMN1; SMN2LMNAMEN1 | |
| SCHEMBL30201017 | 0.79 | MTNR1A (0.45) | MTNR1AMTNR1BLMNAALDH1A1 | |
| SCHEMBL30201393 | 0.75 | MTNR1A (0.48) | MTNR1AMTNR1B | |
| SCHEMBL30201042 | 0.75 | MTNR1A (0.56) | MTNR1AMTNR1BSMN1; SMN2LMNAMEN1 | |
| SCHEMBL30200758 | 0.74 | MTNR1A (0.47) | MTNR1AMTNR1BLMNAKMT2AALDH1A1 | |
| SCHEMBL30200979 | 0.74 | MTNR1A (0.47) | MTNR1AMTNR1BMEN1KMT2AALDH1A1 | |
| SCHEMBL30201055 | 0.74 | ALDH1A1 (0.47) | MTNR1AMTNR1BLMNAKMT2AMAPT | |
| SCHEMBL11117603 | 0.72 | MAPT (0.56) | MTNR1AMTNR1BSMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023028086-A1 | COMBINATIONS OF PERIPHERAL 5-HT2A RECEPTOR ANTAGONISTS AND CENTRAL 5-HT2A RECEPTOR AGONISTS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |