Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.38 |
| ▸ | CCR5 | P51681 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025622 | 0.84 | ALDH1A1 (0.43) | RORCCCR5CNR2DRD2DRD3 | |
| SCHEMBL3029711 | 0.83 | DRD2 (0.40) | RORCCCR5CNR2CHRM4DRD2 | |
| SCHEMBL28030659 | 0.83 | CCR5 (0.42) | RORCCCR5CNR2SIGMAR1 | |
| SCHEMBL3019414 | 0.80 | TACR1 (0.39) | RORCCCR5CNR2CHRM4 | |
| SCHEMBL3029997 | 0.80 | CCR5 (0.44) | RORCCCR5CNR2DRD2DRD3 | |
| SCHEMBL28030186 | 0.80 | RORC (0.45) | RORCCCR5CNR2SIGMAR1 | |
| SCHEMBL3029620 | 0.78 | CCR5 (0.44) | RORCCCR5CNR2DRD2DRD3 | |
| SCHEMBL2778394 | 0.78 | CHEK1 (0.44) | CHEK1CHEK2 | |
| SCHEMBL3019489 | 0.77 | RORC (0.43) | RORCCCR5CNR2CHRM4DRD2 | |
| SCHEMBL3030612 | 0.76 | CCR5 (0.46) | RORCCCR5DRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398768-B1 | PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2016-08-24 | — | — | EP | disclosed |
| CN-102307853-B | As the pyrrolidin derivatives of NK3 receptor antagonist | F. HOFFMANN-LA ROCHE AG (CH) | 2015-09-02 | — | — | CN | disclosed |
| US-8318759-B2 | Pyrrolidine derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20100210659-A1 | PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210659-A1 | PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | OPRL1, OPRK1, OPRD1 | RORC 1018/4885CHEK1 2300/4885CCR5 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.