Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380011 | 0.95 | DAGLA (0.55) | DAGLACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3376229 | 0.89 | ALDH1A1 (0.53) | L3MBTL1ALDH1A1HPGDHTTPTGES | |
| SCHEMBL302098 | 0.87 | KEAP1 (0.49) | L3MBTL1ALDH1A1HPGDHTTPTGES | |
| SCHEMBL3378121 | 0.78 | MAPT (0.46) | L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL3378020 | 0.76 | MEN1 (0.55) | ALDH1A1GAAPKMATMLMNA | |
| SCHEMBL302225 | 0.76 | LMNA (0.60) | ALDH1A1HTTPTGESGAALMNA | |
| SCHEMBL303366 | 0.76 | L3MBTL1 (0.56) | CYP2D6CYP2C9CYP2C19L3MBTL1ALDH1A1 | |
| SCHEMBL301844 | 0.74 | KEAP1 (0.49) | L3MBTL1ALDH1A1HPGDHTTPTGES | |
| SCHEMBL302970 | 0.74 | LMNA (0.59) | ALDH1A1HPGDHTTGAATSHR | |
| SCHEMBL3376926 | 0.74 | MAPT (0.60) | L3MBTL1ALDH1A1HTTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | disclosed |