Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4226890 | 0.92 | KMT2A (0.53) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL7734040 | 0.88 | KMT2A (0.49) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL21565611 | 0.85 | GSK3B (0.59) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL1156727 | 0.85 | KMT2A (0.49) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL2884408 | 0.85 | L3MBTL1 (0.50) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL1156528 | 0.84 | KMT2A (0.69) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL6284563 | 0.84 | HDAC3 (0.54) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL29114074 | 0.83 | KMT2A (0.58) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL12265856 | 0.81 | KMT2A (0.51) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL16044467 | 0.80 | MAPT (0.57) | KMT2AMEN1NPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970193-B1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC (US) | 2018-07-25 | — | — | EP | disclosed |
| US-9493411-B2 | Pyrrole-3-carboxamide bromodomain inhibitors | ABBVIE INC. (US) | 2016-11-15 | — | — | US | disclosed |
| EP-2970193-A1 | PYRROLE AMIDE INHIBITORS | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| CN-105164113-A | Pyrroloamide inhibitors | ABBVIE INC | 2015-12-16 | — | — | CN | disclosed |
| WO-2014165127-A1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| US-20140275079-A1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC. | 2014-09-18 | — | — | US | disclosed |
| US-8609713-B2 | Pyrrole derivatives and their methods of use | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20100216748-A1 | Pyrrole Derivatives and Their Methods of Use | ABBOTT LABORATORIES (US) | 2010-08-26 | — | — | US | disclosed |
| US-7741364-B2 | Neuronal nicotinic acetylcholine receptor modulators; such as ethyl 1-[4-(aminosulfonyl)phenyl]-5-(4-bromophenyl)-2-methyl-1H-pyrrole-3-carboxylate | ABBOTT LABORATORIES (US) | 2010-06-22 | — | — | US | disclosed |
| CN-101479241-A | Pyrrole derivatives and their methods of use | ABBOTT LAB (US) | 2009-07-08 | — | — | CN | disclosed |
| EP-2041085-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | Abbott Laboratories (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080064695-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | ABBVIE INC. | 2008-03-13 | — | — | US | disclosed |
| WO-2008002974-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | ABBOTT LABORATORIES (US) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064695-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | PYCR1, PPOX, DHPS | KMT2A 2578/4885MEN1 2853/4885NPC1 3463/4885 |
| US-20140275079-A1 | PYRROLE AMIDE INHIBITORS | HDAC10, ARG1, CDK20 | KMT2A 2286/4885MEN1 2506/4885NPC1 2843/4885 |
| US-20100216748-A1 | Pyrrole Derivatives and Their Methods of Use | PYCR1, PPOX, DHPS | KMT2A 2578/4885MEN1 2853/4885NPC1 3463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.