Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 4/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033663 | 0.73 | DHFR (0.34) | DHFR | |
| SCHEMBL4972839 | 0.70 | ALDH1A1 (0.41) | — | |
| SCHEMBL2951209 | 0.70 | KDM4E (0.42) | PI4KAPI4K2BPI4K2API4KBCDK1 | |
| SCHEMBL2950165 | 0.69 | TLR7 (0.41) | PI4KAPI4K2BPI4K2API4KBCDK1 | |
| SCHEMBL3040612 | 0.68 | PI4KA (0.42) | PI4KAPI4K2BPI4K2API4KBCDK1 | |
| SCHEMBL2951937 | 0.67 | DHFR (0.45) | PI4KAPI4K2BPI4K2API4KBCDK1 | |
| SCHEMBL2955288 | 0.67 | TLR7 (0.42) | PI4KAPI4K2BPI4K2API4KBCDK1 | |
| SCHEMBL2952316 | 0.66 | NPC1 (0.51) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2953257 | 0.66 | CDK1 (0.42) | PI4KAPI4K2BPI4K2API4KBCDK1 | |
| SCHEMBL2946546 | 0.65 | PI4KA (0.37) | PI4KAPI4K2BPI4K2API4KBCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |