Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033667 | 0.73 | PI4KA (0.38) | DHFR | |
| SCHEMBL4972839 | 0.71 | ALDH1A1 (0.41) | GAA | |
| SCHEMBL3040608 | 0.67 | F9 (0.34) | — | |
| SCHEMBL2951931 | 0.67 | PRKDC (0.42) | DHFR | |
| SCHEMBL2955281 | 0.67 | CAMKK2 (0.45) | — | |
| SCHEMBL2953250 | 0.67 | CARM1 (0.40) | DHFRHRH4 | |
| SCHEMBL2952310 | 0.66 | NPC1 (0.50) | GAAHRH4 | |
| SCHEMBL2946541 | 0.66 | CDK1 (0.41) | DHFR | |
| SCHEMBL2946549 | 0.66 | CDK1 (0.32) | DHFRHRH4 | |
| SCHEMBL2953442 | 0.64 | HRH4 (0.42) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |