Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 2/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21616740 | 0.87 | HCAR2 (0.43) | SIRT6LMNAHCAR2PRKCE | |
| SCHEMBL28476138 | 0.85 | MAPK1 (0.41) | LCKLMNAHCAR2 | |
| SCHEMBL30340356 | 0.77 | SIRT6 (0.41) | SIRT6CDK8CDK19SCN9ALCK | |
| SCHEMBL28986848 | 0.74 | LMNA (0.39) | CDK8CDK19LMNAPRKCEATM | |
| SCHEMBL30340388 | 0.71 | PDCD1 (0.43) | SIRT6SCN9A | |
| SCHEMBL29144076 | 0.67 | SIRT6 (0.46) | SIRT6LCKNNMTAPP | |
| SCHEMBL30242017 | 0.67 | SIRT6 (0.46) | SIRT6LCKNNMTAPP | |
| SCHEMBL24959354 | 0.66 | SIRT6 (0.49) | SIRT6NCOA1NCOA3 | |
| SCHEMBL24960002 | 0.66 | SIRT6 (0.49) | SIRT6NNMTAPPNCOA1NCOA3 | |
| SCHEMBL30341012 | 0.66 | CYP4F2 (0.50) | LMNACYP4F2NNMTCYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111886219-B | Immunosuppressant, preparation method and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2023-04-25 | — | — | CN | disclosed |