Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.37 |
| ▸ | CTSS | P25774 | 4/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25188943 | 1.00 | CTSK (0.37) | CTSKCTSSKDM5AALDH1A1MAPK1 | |
| SCHEMBL30442601 | 0.74 | MBOAT4 (0.35) | MBOAT4MEN1KMT2AKDM4E | |
| SCHEMBL25187828 | 0.74 | MBOAT4 (0.35) | MBOAT4MEN1KMT2AKDM4E | |
| SCHEMBL25199463 | 0.72 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL30401929 | 0.72 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL25194933 | 0.71 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2AGRM1KDM4E | |
| SCHEMBL9846221 | 0.70 | CYP1A2 (0.49) | CTSKCTSSKDM5AALDH1A1MEN1 | |
| SCHEMBL102958 | 0.68 | CHEK1 (0.38) | CTSKCTSS | |
| SCHEMBL9846336 | 0.68 | GAA (0.51) | KDM5AALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL28890273 | 0.67 | ALDH1A1 (0.35) | CTSKCTSSALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430022-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | Vigil Neuroscience, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086801-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | VIGIL NEUROSCIENCE, INC. (US) | 2023-05-19 | — | — | WO | disclosed |