SCHEMBL304537

SCHEMBL304537

[CH2]COC(=O)Oc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.43
TDP1 Q9NUW8 2/20 0.43
KDM4E B2RXH2 1/20 0.43
ATM Q13315 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
ALOX15 P16050 2/20 0.42
HSD17B10 Q99714 3/20 0.41
HPGD P15428 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP19A1 P11511 1/20 0.41
THRB P10828 1/20 0.41
MEN1 O00255 1/20 0.40
HTT P42858 1/20 0.40
GFER P55789 1/20 0.40
KMT2A Q03164 1/20 0.40
PRSS1 P07477 1/20 0.39
PRSS2 P07478 1/20 0.39
PRSS3 P35030 1/20 0.39
USP2 O75604 1/20 0.39
NSD2 O96028 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2906295 0.84 THRB (0.42) MAPTTDP1KDM4EATML3MBTL1
SCHEMBL8646552 0.83 THRB (0.47) MAPTTDP1KDM4EATML3MBTL1
SCHEMBL10025073 0.83 MAPT (0.46) MAPTTDP1KDM4EATML3MBTL1
SCHEMBL2900757 0.81 TDP1 (0.43) MAPTTDP1KDM4EATML3MBTL1
SCHEMBL6895096 0.81 MAPT (0.44) MAPTTDP1KDM4EATML3MBTL1
SCHEMBL322125 0.81 MAPT (0.44) MAPTTDP1KDM4EATML3MBTL1
SCHEMBL10025075 0.81 MAPT (0.44) MAPTTDP1KDM4EATML3MBTL1
Ethylene SCHEMBL23748028 0.80 MAPT (0.41) MAPTTDP1KDM4EATML3MBTL1
Ethylene SCHEMBL2021059 0.80 TDP1 (0.50) MAPTTDP1KDM4EATML3MBTL1
SCHEMBL18073 0.79 TDP1 (0.54) MAPTTDP1KDM4EATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 304 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5283326-A Coupling azo and cyanine dyes; colorfastness, heat resistance SANDOZ AG (CH) 1994-02-01 US claimed
US-4837269-A FIBER-REACTIVE DISAZO DYES BASF AKTIENGESELLSCHAFT (DE) 1989-06-06 US claimed
US-4751288-A COLORFASTNESS BASF AKTIENGESELLSCHAFT (DE) 1988-06-14 US claimed
US-4619992-A IMPROVED COLORFASTNESS BASF AKTIENGESELLSCHAFT (DE) 1986-10-28 US claimed
US-4560751-A CYCLIZATION OF AMIDO-THIOAMIDE COMPOUND BASF AKTIENGESELLSCHAFT (DE) 1985-12-24 US claimed
US-4496480-A Isothiazolazo dyes having coupling components which are free from unsaturated aliphatic radicals BASF AKTIENGESELLSCHAFT (DE) 1985-01-29 US claimed
US-4250090-A COLORFASTNESS; WETFASTNESS; ACID AZO DYES BASF AKTIENGESELLSCHAFT (DE) 1981-02-10 US claimed
US-12023316-B2 FAP-activated therapeutic agents, and uses related thereto BACH BIOSCIENCES, LLC (US) 2024-07-02 US disclosed
CN-113967258-B FAP-activated therapeutic agents and related uses 塔夫茨大学信托人 2024-07-02 CN disclosed
CN-118109069-A Resin composition, cured product, and method for producing cured product 东京应化工业株式会社 2024-05-31 CN disclosed
CN-118108899-A Curable resin composition, cured product, and method for producing cured product 东京应化工业株式会社 2024-05-31 CN disclosed
US-11925655-B2 FAP-activated therapeutic agents, and uses related thereto BACH BIOSCIENCES, LLC (US) 2024-03-12 US disclosed
EP-4299134-A2 FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO Bach Biosciences, LLC (US) 2024-01-03 EP disclosed
EP-0034716-A1 Navy blue dyestuff mixtures and their use in dyeing polyesters BASF Aktiengesellschaft (DE) 1981-09-02 EP disclosed
US-4283331-A FIBER-REACTIVE DYES CIBA-GEIGY CORPORATION (US) 1981-08-11 US disclosed
US-4250090-A COLORFASTNESS; WETFASTNESS; ACID AZO DYES BASF AKTIENGESELLSCHAFT (DE) 1981-02-10 US disclosed
US-4243809-A 5-SULFONYL-6-HYDROXYPYRIDONES OR THE 3-CARBAMOYL DERIVATIVES; SULFONYLATION WITH AN ALKYL SULFONYL HALIDE CIBA-GEIGY CORPORATION (US) 1981-01-06 US disclosed
US-4234482-A Substituted 3-carbalkoxy 4-alkylamino-azobenzene compound as disperse dyestuffs for synthetic fibers PRODUITS CHIMIQUES UGINE KUHLMANN SERVICE PROPRIETE INDUSTRIELLE (FR) 1980-11-18 US disclosed
US-4207233-A Azo dyes containing a thiazole component BASF AKTIENGESELLSCHAFT (DE) 1980-06-10 US disclosed
US-4180503-A FOR DYEING POLYAMIDES BAYER AKTIENGESELLSCHAFT (DE) 1979-12-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12023316-B2 FAP-activated therapeutic agents, and uses related thereto FAP, FIBP, GOT1 MAPT 3925/4885TDP1 322/4885KDM4E 2409/4885
US-11925655-B2 FAP-activated therapeutic agents, and uses related thereto FAP, FIBP, GOT1 MAPT 3856/4885TDP1 834/4885KDM4E 2044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.