Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | HRH2 | P25021 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR1E | P28566 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662051 | 0.89 | MGLL (0.58) | MGLLALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6005510 | 0.86 | MAPT (0.67) | ALDH1A1KMT2AHTR1ALMNAMAPT | |
| SCHEMBL11162215 | 0.83 | KCNH2 (0.60) | ALDH1A1TMEM97SIGMAR1SLC6A2HRH2 | |
| SCHEMBL10763277 | 0.82 | HTR1A (0.65) | ALDH1A1HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL5781834 | 0.82 | MAPT (0.73) | MGLLALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL27467416 | 0.82 | SIGMAR1 (0.53) | ALDH1A1MEN1KMT2ASIGMAR1DRD2 | |
| SCHEMBL11628265 | 0.81 | DRD2 (0.66) | ALDH1A1TMEM97SIGMAR1SLC6A2HRH2 | |
| SCHEMBL11168983 | 0.81 | TMEM97 (0.54) | MGLLALDH1A1TMEM97SIGMAR1SLC6A2 | |
| SCHEMBL14220881 | 0.81 | HTR7 (0.54) | ALDH1A1MEN1KMT2ADRD2DRD3 | |
| SCHEMBL3056132 | 0.81 | MGLL (0.51) | MGLLALDH1A1DRD2DRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183227-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LTD (GB) | 2014-09-24 | — | — | EP | disclosed |
| EP-2183227-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LTD (GB) | 2014-09-24 | — | — | EP | disclosed |
| CN-101827828-B | 1, 2, 4 -triazole derivatives as serotonergic modulators | PROSARIX LTD | 2013-02-27 | — | — | CN | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| CN-101827828-A | 1, 2, 4 -triazole derivatives as serotonergic modulators | PROSARIX LTD | 2010-09-08 | — | — | CN | disclosed |
| EP-2183227-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | Prosarix Limited (GB) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009019472-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009019472-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | HTR1A, HTR5A, TPH1 | MGLL 2628/4885ALDH1A1 2185/4885MEN1 2932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.