Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30567123 | 0.89 | MTNR1B (0.54) | L3MBTL1LMNAPOLBRAB9AALDH1A1 | |
| SCHEMBL31522156 | 0.85 | LMNA (0.43) | L3MBTL1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL25386869 | 0.84 | L3MBTL1 (0.68) | L3MBTL1LMNAPOLBADRA2CATM | |
| SCHEMBL25386870 | 0.84 | L3MBTL1 (0.68) | L3MBTL1LMNAPOLBADRA2CATM | |
| SCHEMBL1341273 | 0.84 | ADRA2C (0.56) | L3MBTL1LMNAPOLBADRA2CATM | |
| SCHEMBL8347748 | 0.81 | PGR (0.53) | LMNAPOLBGAARAB9AALDH1A1 | |
| SCHEMBL15020425 | 0.81 | HPGD (0.51) | LMNAPOLBGAARAB9AALDH1A1 | |
| SCHEMBL11901156 | 0.80 | CTSS (0.43) | LMNAPOLBATMALDH1A1MEN1 | |
| SCHEMBL9286086 | 0.80 | AAK1 (0.51) | LMNAPOLBALDH1A1MAPK1KDM4E | |
| SCHEMBL9283981 | 0.80 | AAK1 (0.51) | LMNAPOLBALDH1A1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250171404-A1 | PCNA INHIBITORS AND USES THEREOF | UNITED STATES GOVERNMENT | 2025-05-29 | — | — | US | disclosed |
| EP-4490142-A2 | PCNA INHIBITORS AND USES THEREOF | City of Hope (US) | 2025-01-15 | — | — | EP | disclosed |
| WO-2023172880-A2 | PCNA INHIBITORS AND USES THEREOF | CITY OF HOPE (US) | 2023-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171404-A1 | PCNA INHIBITORS AND USES THEREOF | PCNA, MKI67, PCLAF | L3MBTL1 1817/4885LMNA 1607/4885POLB 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.