Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 5/20 | 0.62 |
| ▸ | DRD4 | P21917 | 3/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.58 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054710 | 0.82 | DRD2 (0.61) | MAPK1HTR1ADRD4DRD2DRD3 | |
| SCHEMBL3056156 | 0.81 | HTR1A (0.68) | MAPK1HTR1ADRD4DRD2DRD3 | |
| SCHEMBL3160665 | 0.80 | HTR1A (0.79) | HTR1ADRD2DRD3KMT2AHTR7 | |
| Benzene SCHEMBL10433203 | 0.80 | HTR1A (0.79) | HTR1ADRD2DRD3KMT2AHTR7 | |
| SCHEMBL3055774 | 0.80 | DRD2 (0.62) | HTR1ADRD4DRD2DRD3HTR7 | |
| SCHEMBL14007328 | 0.80 | HTR7 (0.69) | MAPK1HTR1ADRD2DRD3KMT2A | |
| SCHEMBL17946113 | 0.79 | DRD2 (0.73) | MAPK1HTR1ADRD4DRD2DRD3 | |
| SCHEMBL8443516 | 0.79 | HTR1A (0.65) | MAPK1HTR1ADRD4DRD2KMT2A | |
| SCHEMBL3060697 | 0.79 | MAPK1 (0.55) | MAPK1HTR1ADRD4DRD2DRD3 | |
| SCHEMBL17946603 | 0.77 | CACNA1G (0.72) | MAPK1HTR1AKMT2ACACNA1GMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183227-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LTD (GB) | 2014-09-24 | — | — | EP | disclosed |
| EP-2183227-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LTD (GB) | 2014-09-24 | — | — | EP | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| WO-2009019472-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | HTR1A, HTR5A, TPH1 | MAPK1 1970/4885HTR1A 1/4885DRD4 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.