Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | RECQL | P46063 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340747 | 0.92 | RAB9A (0.83) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL9642715 | 0.91 | NPC1 (0.89) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL14839601 | 0.87 | ALDH1A1 (0.76) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL10582387 | 0.87 | ALDH1A1 (0.76) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL9187561 | 0.86 | NPC1 (1.00) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL3463529 | 0.85 | NPC1 (0.77) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL1340160 | 0.83 | NPC1 (0.74) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL12497335 | 0.83 | RAB9A (0.68) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL3451500 | 0.83 | NPC1 (0.79) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL3464612 | 0.83 | NPC1 (0.79) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913714-B2 | Pyrrole sulfonyl derivative, preparation method and medical use thereof | JIANGSU CAREPHAR PHARMACEUTICAL CO., LTD (CN) | 2021-02-09 | — | — | US | disclosed |
| EP-3694856-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-08-19 | — | — | EP | disclosed |
| CN-107207432-B | Pyrroles's sulphonyl analog derivative, preparation method and its application in medicine | 江苏柯菲平医药股份有限公司 | 2019-09-17 | — | — | CN | disclosed |
| EP-3248963-B1 | PYRROLE SULFONYL DERIVATIVE, AND PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU CAREPHAR PHARMACEUTICAL CO LTD (CN) | 2019-07-17 | — | — | EP | disclosed |
| WO-2019100735-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-05-31 | — | — | WO | disclosed |
| WO-2018219356-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-12-06 | — | — | WO | disclosed |
| US-20180009749-A1 | Pyrrole Sulfonyl Derivative, Preparation Method and Medical Use thereof | JIANGSU CAREFREE PHARMACEUTICAL CO., LTD (CN) | 2018-01-11 | — | — | US | disclosed |
| EP-3248963-A1 | PYRROLE SULFONYL DERIVATIVE, AND PREPARATION METHOD AND MEDICAL USE THEREOF | Jiangsu Carephar Pharmaceutical Co., Ltd (CN) | 2017-11-29 | — | — | EP | disclosed |
| CN-107207432-A | Pyrroles's sulphonyl analog derivative, its preparation method and its in application pharmaceutically | 江苏柯菲平医药股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-105985278-A | Pyrrole sulfonyl derivatives, preparation method and medicinal application thereof | 江苏柯菲平医药股份有限公司 | 2016-10-05 | — | — | CN | disclosed |
| US-7842688-B2 | Organic compounds | NOVARTIS PHARMA AG (CH) | 2010-11-30 | — | — | US | disclosed |
| US-7790715-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-07 | — | — | US | disclosed |
| US-20090012055-A1 | Organic compounds | HEROLD PETER | 2009-01-08 | — | — | US | disclosed |
| EP-1961752-A2 | Piperidine Compounds | Speedel Experimenta AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| US-20070010511-A1 | Organic compounds | NOVARTIS PHARMA AG (CH) | 2007-01-11 | — | — | US | disclosed |
| EP-1670760-A1 | ORGANIC COMPOUNDS | Speedel Experimenta AG (CH) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005061457-A1 | ORGANIC COMPOUNDS | SPEEDEL EXPERIMENTA AG (CH) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012055-A1 | Organic compounds | REN, ACE, ACE2 | RAB9A 1066/4885NPC1 794/4885RECQL 2060/4885 |
| US-20070010511-A1 | Organic compounds | REN, ACE, ACE2 | RAB9A 1066/4885NPC1 794/4885RECQL 2060/4885 |
| US-20180009749-A1 | Pyrrole Sulfonyl Derivative, Preparation Method and Medical Use thereof | GIPR, PGC, ABCB11 | RAB9A 682/4885NPC1 2018/4885RECQL 2743/4885 |
| US-10913714-B2 | Pyrrole sulfonyl derivative, preparation method and medical use thereof | GIPR, PGC, ABCB11 | RAB9A 682/4885NPC1 2018/4885RECQL 2743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.