SCHEMBL30711979

SCHEMBL30711979

C[Si](C)(C)COC(=O)NC1CCN(C(=O)O)CC1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
HSD11B1 P28845 3/20 0.39
EPHX2 P34913 6/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
THRB P10828 1/20 0.37
ATM Q13315 1/20 0.37
EPHX1 P07099 3/20 0.36
LMNA P02545 2/20 0.36
POLB P06746 1/20 0.36
MAPK1 P28482 1/20 0.36
GAA P10253 1/20 0.35
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21397787 0.80 EPHX1 (0.53) EPHX2EPHX1ALDH1A1
SCHEMBL27877748 0.79 EPHX2 (0.43) KMT2AMEN1EPHX2EPHX1POLB
SCHEMBL8534730 0.78 SMN1; SMN2 (0.49) KMT2AMEN1HSD11B1EPHX2L3MBTL1
SCHEMBL3936610 0.78 KMT2A (0.41) KMT2AMEN1HSD11B1EPHX2L3MBTL1
SCHEMBL3937465 0.77 KMT2A (0.46) KMT2AMEN1HSD11B1EPHX2L3MBTL1
SCHEMBL30807383 0.74 HSD11B1 (0.61) KMT2AMEN1HSD11B1L3MBTL1THRB
SCHEMBL27147272 0.74 HSD11B1 (0.61) KMT2AMEN1HSD11B1L3MBTL1THRB
SCHEMBL6187601 0.73 CTSK (0.56) HSD11B1EPHX1GAA
SCHEMBL1870932 0.72 ALDH1A1 (0.67) KMT2AMEN1HSD11B1EPHX1GAA
SCHEMBL5361247 0.71 EPHX2 (0.50) EPHX2ATMEPHX1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023222115-A1 HYDROXYAMIDE DERIVATIVE AND USE THEREOF 四川汇宇制药股份有限公司 2023-11-23 WO disclosed