Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13143624 | 0.80 | SMN1; SMN2 (0.49) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2GAA | |
| SCHEMBL11388939 | 0.77 | SMN1; SMN2 (0.56) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2GAA | |
| SCHEMBL3082339 | 0.75 | LMNA (0.47) | ALDH1A1SMN1; SMN2GAALMNAKMT2A | |
| SCHEMBL3084837 | 0.75 | LMNA (0.43) | ALDH1A1SMN1; SMN2GAALMNAKMT2A | |
| SCHEMBL1658169 | 0.70 | SMN1; SMN2 (0.52) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2GAA | |
| SCHEMBL102338 | 0.70 | SIGMAR1 (0.71) | ALDH1A1SMN1; SMN2LMNAKMT2AHTT | |
| SCHEMBL6200777 | 0.70 | SIGMAR1 (0.71) | ALDH1A1SMN1; SMN2LMNAKMT2AHTT | |
| SCHEMBL4590541 | 0.70 | ALDH1A1 (0.64) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2GAA | |
| SCHEMBL28975291 | 0.70 | NPC1 (0.59) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2GAA | |
| SCHEMBL27174954 | 0.69 | LMNA (0.42) | ALDH1A1CYP3A4SMN1; SMN2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795442-B2 | Preparation of thiazoles | SYNGENTA CROP PROTECTION, INC. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090198054-A1 | PREPARATION OF THIAZOLES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-08-06 | — | — | US | disclosed |
| US-7538229-B2 | Preparation of thiazoles | SYNGENTA CROP PROTECTION, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-20080076920-A1 | PREPARATION OF THIAZOLES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| US-7323564-B2 | Preparation of thiazoles | SYNGENTA CROP PROTECTION, INC. (US) | 2008-01-29 | — | — | US | disclosed |
| US-20070055063-A1 | PREPARATION OF THIAZOLES | SYNGENTA CROP PROTECTION, INC. (US) | 2007-03-08 | — | — | US | disclosed |
| US-7161011-B2 | Reactin a thiazole compound with glycidyl aldehyde | SYNGENTA CROP PROTECTION, INC. (US) | 2007-01-09 | — | — | US | disclosed |
| EP-1201662-B1 | Preparation of thiazoles | SYNGENTA PARTICIPATIONS AG (CH) | 2005-10-26 | — | — | EP | disclosed |
| EP-1577307-A2 | Preparation of thiazoles | Syngenta Participations AG (CH) | 2005-09-21 | — | — | EP | disclosed |
| US-20030216579-A1 | Preparation of thiazoles | PITTERNA THOMAS (CH) | 2003-11-20 | — | — | US | disclosed |
| US-6548676-B1 | Halogenation or sulfonylation of 5-methylol-2-sulfanyl-thiazole derivatives; separation, salt formation | SYNGENTA CROP PROTECTION, INC. | 2003-04-15 | — | — | US | disclosed |
| EP-0946532-B1 | PREPARATION OF THIAZOLES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-07-17 | — | — | EP | disclosed |
| EP-1201662-A1 | Preparation of thiazoles | Syngenta Participations AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| EP-0946532-A1 | PREPARATION OF THIAZOLES | Novartis AG (CH) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027075-A1 | PREPARATION OF THIAZOLES | NOVARTIS AG (CH) | 1998-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076920-A1 | PREPARATION OF THIAZOLES | OXSR1, OSR1, OSBPL3 | ALDH1A1 4350/4885CYP3A4 2397/4885CYP2C19 2900/4885 |
| US-20070055063-A1 | PREPARATION OF THIAZOLES | SLC5A1, TST, TCOF1 | ALDH1A1 1685/4885CYP3A4 512/4885CYP2C19 801/4885 |
| US-20090198054-A1 | PREPARATION OF THIAZOLES | OXSR1, OSR1, OSBPL3 | ALDH1A1 4350/4885CYP3A4 2397/4885CYP2C19 2900/4885 |
| US-20030216579-A1 | Preparation of thiazoles | CBR1, CBR3, SULT1A1 | ALDH1A1 287/4885CYP3A4 137/4885CYP2C19 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.