SCHEMBL307963

SCHEMBL307963

CS(=O)(Cc1cnc(Cl)s1)=NC#N

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.46
KMT2A Q03164 2/20 0.46
ALDH1A1 P00352 2/20 0.36
MEN1 O00255 1/20 0.35
L3MBTL1 Q9Y468 5/20 0.35
GAA P10253 1/20 0.33
CDK2 P24941 1/20 0.33
CDK9 P50750 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
POLB P06746 1/20 0.33
RAB9A P51151 1/20 0.33
ATM Q13315 1/20 0.33
SLC6A3 Q01959 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7602154 0.85 SLC6A3 (0.34) LMNAKMT2ACDK2CDK9SLC6A3
SCHEMBL16116600 0.81 KMT2A (0.50) LMNAKMT2AALDH1A1MEN1L3MBTL1
SCHEMBL305535 0.80 CDK2 (0.34) CDK2CDK9
SCHEMBL3536702 0.77 KMT2A (0.56) LMNAKMT2AALDH1A1MEN1L3MBTL1
SCHEMBL3084435 0.72 SLC6A3 (0.33) CDK2CDK9SLC6A3
SCHEMBL2745638 0.71 CDK2 (0.35) CDK2CDK9
SCHEMBL9610888 0.70 CDK2 (0.39) GAACDK2CDK9
SCHEMBL14997368 0.70 CDK2 (0.34) CDK2CDK9
SCHEMBL3285457 0.69 CDK2 (0.43) CDK2CDK9
SCHEMBL14205741 0.69 CDK2 (0.37) ALDH1A1CDK2CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2012500816-A 2012-01-12 JP claimed
EP-2381781-A1 METHOD FOR IMPROVED USE OF THE PRODUCTION POTENTIAL OF GENETICALLY MODIFIED PLANTS Bayer CropScience AG (DE) 2011-11-02 EP claimed
EP-2323488-A2 METHOD FOR IMPROVING PLANT GROWTH Bayer CropScience AG (DE) 2011-05-25 EP claimed
EP-2223602-A1 Method for improved utilisation of the production potential of genetically modified plants Bayer CropScience AG (DE) 2010-09-01 EP claimed
WO-2010075966-A1 METHOD FOR IMPROVED USE OF THE PRODUCTION POTENTIAL OF GENETICALLY MODIFIED PLANTS BAYER CROPSCIENCE AG (DE) 2010-07-08 WO claimed
WO-2010022897-A2 METHOD FOR IMPROVING PLANT GROWTH BAYER CROPSCIENCE AG (DE) 2010-03-04 WO claimed
EP-2323488-B1 METHOD FOR IMPROVING PLANT GROWTH BAYER IP GMBH (DE) 2018-04-18 EP disclosed
US-9763451-B2 Method for improved use of the production potential of genetically modified plants BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-19 US disclosed
US-9763451-B2 Method for improved use of the production potential of genetically modified plants BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-19 US disclosed
US-9763451-B2 Method for improved use of the production potential of genetically modified plants BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-19 US disclosed
EP-1732895-B1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2016-11-16 EP disclosed
EP-2381781-B1 METHOD FOR IMPROVED USE OF THE PRODUCTION POTENTIAL OF GENETICALLY MODIFIED PLANTS BAYER IP GMBH (DE) 2016-06-08 EP disclosed
US-20160044921-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS BAYER CROPSCIENCE AG (DE) 2016-02-18 US disclosed
WO-2010022897-A2 METHOD FOR IMPROVING PLANT GROWTH BAYER CROPSCIENCE AG (DE) 2010-03-04 WO disclosed
WO-2010022897-A2 METHOD FOR IMPROVING PLANT GROWTH BAYER CROPSCIENCE AG (DE) 2010-03-04 WO disclosed
US-20100056578-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-04 US disclosed
US-20100056579-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-04 US disclosed
US-20100056579-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-04 US disclosed
WO-2009135613-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2009-11-12 WO disclosed
WO-2009135613-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2009-11-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056579-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS LMNA 4737/4885KMT2A 861/4885ALDH1A1 3325/4885
US-20160044921-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS ACHE, ACAT2, ACAT1 LMNA 3728/4885KMT2A 3793/4885ALDH1A1 1248/4885
US-20100056578-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS LMNA 4737/4885KMT2A 861/4885ALDH1A1 3325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.