SCHEMBL305535

SCHEMBL305535

CS(=O)(Cc1cnc(C(F)(F)F)s1)=NC#N

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 6/20 0.34
CDK9 P50750 6/20 0.34
HDAC6 Q9UBN7 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12613852 0.83 HDAC6 (0.31) HDAC6
SCHEMBL307963 0.80 LMNA (0.46) CDK2CDK9
SCHEMBL7602154 0.80 SLC6A3 (0.34) CDK2CDK9
SCHEMBL1997902 0.73
SCHEMBL1990893 0.73 CDK2 (0.32) CDK2CDK9
SCHEMBL18641548 0.73 CACNA1G (0.31)
SCHEMBL1787038 0.72 PDE9A (0.33)
SCHEMBL17804549 0.71 PDE9A (0.30)
SCHEMBL119494 0.70 CDK2 (0.39) CDK2CDK9
SCHEMBL16388288 0.70 CNR2 (0.31) HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2012500816-A 2012-01-12 JP claimed
EP-2381781-A1 METHOD FOR IMPROVED USE OF THE PRODUCTION POTENTIAL OF GENETICALLY MODIFIED PLANTS Bayer CropScience AG (DE) 2011-11-02 EP claimed
EP-2323488-A2 METHOD FOR IMPROVING PLANT GROWTH Bayer CropScience AG (DE) 2011-05-25 EP claimed
EP-2223602-A1 Method for improved utilisation of the production potential of genetically modified plants Bayer CropScience AG (DE) 2010-09-01 EP claimed
WO-2010075966-A1 METHOD FOR IMPROVED USE OF THE PRODUCTION POTENTIAL OF GENETICALLY MODIFIED PLANTS BAYER CROPSCIENCE AG (DE) 2010-07-08 WO claimed
WO-2010022897-A2 METHOD FOR IMPROVING PLANT GROWTH BAYER CROPSCIENCE AG (DE) 2010-03-04 WO claimed
EP-2323488-B1 METHOD FOR IMPROVING PLANT GROWTH BAYER IP GMBH (DE) 2018-04-18 EP disclosed
US-9763451-B2 Method for improved use of the production potential of genetically modified plants BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-19 US disclosed
US-9763451-B2 Method for improved use of the production potential of genetically modified plants BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-19 US disclosed
EP-2381781-B1 METHOD FOR IMPROVED USE OF THE PRODUCTION POTENTIAL OF GENETICALLY MODIFIED PLANTS BAYER IP GMBH (DE) 2016-06-08 EP disclosed
US-20160044921-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS BAYER CROPSCIENCE AG (DE) 2016-02-18 US disclosed
US-20140287915-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS BAYER CROPSCIENCE AG (DE) 2014-09-25 US disclosed
US-20140287915-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS BAYER CROPSCIENCE AG (DE) 2014-09-25 US disclosed
WO-2009135613-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2009-11-12 WO disclosed
EP-2057135-A1 INSECTICIDAL N-SUBSTITUTED (2- SUDSTITUTED-1,3-THIAZOL) ALKYL SULFOXIMINES Dow AgroSciences LLC (US) 2009-05-13 EP disclosed
WO-2008027539-A1 INSECTICIDAL N-SUBSTITUTED (2- SUDSTITUTED-1,3-THIAZOL) ALKYL SULFOXIMINES DOW AGROSCIENCES LLC (US) 2008-03-06 WO disclosed
WO-2008027539-A1 INSECTICIDAL N-SUBSTITUTED (2- SUDSTITUTED-1,3-THIAZOL) ALKYL SULFOXIMINES DOW AGROSCIENCES LLC (US) 2008-03-06 WO disclosed
US-20080058394-A1 Insecticidal N-substituted (2-substituted-1,3-thiazol)alkyl sulfoximines DOW AGROSCIENCES LLC (US) 2008-03-06 US disclosed
US-20080058394-A1 Insecticidal N-substituted (2-substituted-1,3-thiazol)alkyl sulfoximines DOW AGROSCIENCES LLC (US) 2008-03-06 US disclosed
US-20080058394-A1 Insecticidal N-substituted (2-substituted-1,3-thiazol)alkyl sulfoximines DOW AGROSCIENCES LLC (US) 2008-03-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160044921-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS ACHE, ACAT2, ACAT1 CDK2 1670/4885CDK9 1640/4885HDAC6 13/4885
US-20080058394-A1 Insecticidal N-substituted (2-substituted-1,3-thiazol)alkyl sulfoximines TST, NIT2, MSL1 CDK2 2909/4885CDK9 4413/4885HDAC6 301/4885
US-20140287915-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS ACHE, ACAT2, ACAT1 CDK2 1670/4885CDK9 1640/4885HDAC6 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.