SCHEMBL308466

SCHEMBL308466

Cc1cccc(-c2nccn2CCCCCCN)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.41
CCR8 P51685 1/20 0.41
SIK2 Q9H0K1 3/20 0.39
SIK1 P57059 1/20 0.39
SIK3 Q9Y2K2 1/20 0.39
STK4 Q13043 2/20 0.38
STK3 Q13188 2/20 0.38
STK26 Q9P289 2/20 0.38
STK24 Q9Y6E0 2/20 0.38
BRD4 O60885 1/20 0.38
TLR8 Q9NR97 3/20 0.38
TGFBR1 P36897 5/20 0.38
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.36
KMT2A Q03164 1/20 0.36
HASPIN Q8TF76 1/20 0.36
CXCR4 P61073 1/20 0.36
CYP2A6 P11509 1/20 0.35
TGFBR2 P37173 1/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28865099 0.99 CCR1 (0.40) CCR1CCR8SIK2SIK1SIK3
SCHEMBL308320 0.80 ALDH1A1 (0.52) ALDH1A1KMT2ACYP2C19
SCHEMBL24575513 0.76 TLR8 (0.36) BRD4TLR8ALDH1A1POLBKMT2A
SCHEMBL8910757 0.75 ESR1 (0.59) BRD4TLR8ALDH1A1POLBKMT2A
Hydrochloric Acid SCHEMBL7182475 0.75 ALDH1A1 (0.57) TLR8ALDH1A1POLBKMT2ACYP3A4
Hydrochloric Acid SCHEMBL7182544 0.75 ALDH1A1 (0.57) TLR8ALDH1A1POLBKMT2ACYP3A4
Hydrochloric Acid SCHEMBL7177948 0.75 ALDH1A1 (0.57) TLR8ALDH1A1POLBKMT2ACYP3A4
Hydrochloric Acid SCHEMBL7178422 0.75 ALDH1A1 (0.57) TLR8ALDH1A1POLBKMT2ACYP3A4
Hydrochloric Acid SCHEMBL7178580 0.75 ALDH1A1 (0.57) TLR8ALDH1A1POLBKMT2ACYP3A4
Hydrochloric Acid SCHEMBL7180452 0.75 ALDH1A1 (0.57) TLR8ALDH1A1POLBKMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10219730-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2019-03-05 US disclosed
US-20160296147-A1 Redox Polymers THERASENSE, INC. 2016-10-13 US disclosed
US-9320467-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2016-04-26 US disclosed
US-20140364710-A1 Redox Polymers THERASENSE, INC. 2014-12-11 US disclosed
US-8828204-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2014-09-09 US disclosed
US-8795490-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2014-08-05 US disclosed
US-8637194-B2 Bio-nano power cells and their uses BIO-NANO POWER, LLC (US) 2014-01-28 US disclosed
US-20130330293-A1 BIO-NANO POWER CELLS AND THEIR USES BIO-NANO POWER (US) 2013-12-12 US disclosed
US-8512534-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2013-08-20 US disclosed
US-8168052-B2 Transition metal complexes with bidentate ligand having an imidazole ring ABBOTT DIABETES CARE INC. (US) 2012-05-01 US disclosed
US-8092662-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2012-01-10 US disclosed
US-20110303537-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2011-12-15 US disclosed
US-20110303538-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2011-12-15 US disclosed
US-20110306111-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2011-12-15 US disclosed
US-20100288634-A1 Transition Metal Complexes with Bidentate Ligand Having an Imidazole Ring ABBOTT DIABETES CARE INC. 2010-11-18 US disclosed
EP-1230248-B1 TRANSITION METAL COMPLEXES ATTACHED TO A POLYMER VIA A FLEXIBLE CHAIN THERASENSE INC (US) 2007-06-06 EP disclosed
US-6605200-B1 Charge transfer compounds comprising polymers such as polyvinylpyridine and/or copolymers coupled to osmium compounds, used as biosensors in redox systems THERASENSE, INC. 2003-08-12 US disclosed
EP-1230248-A2 TRANSITION METAL COMPLEXES ATTACHED TO A POLYMER VIA A FLEXIBLE CHAIN Therasense, Inc. (US) 2002-08-14 EP disclosed
WO-2001036660-A2 TRANSITION METAL COMPLEXES ATTACHED TO A POLYMER VIA A FLEXIBLE CHAIN THERASENSE, INC. (US) 2001-05-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130330293-A1 BIO-NANO POWER CELLS AND THEIR USES GPX4, GPX1, LPO CCR1 1219/4885CCR8 1593/4885SIK2 785/4885
US-10219730-B2 Redox polymers PPOX, OTC, ME3 CCR1 4831/4885CCR8 4512/4885SIK2 2612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.