Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNG | P07510 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | CHRND | Q07001 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9311051 | 0.99 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL15820571 | 0.91 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9310147 | 0.90 | OPRM1 (0.50) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL9087003 | 0.85 | XDH (0.40) | BCHE | |
| Hydrochloric Acid SCHEMBL31083972 | 0.83 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL1660644 | 0.83 | OPRM1 (0.61) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL6831189 | 0.83 | OPRM1 (0.61) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL8959911 | 0.82 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL737743 | 0.82 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL4180702 | 0.82 | OPRM1 (0.59) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790898-B2 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2010-09-07 | — | — | US | disclosed |
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-07-26 | — | — | US | disclosed |
| US-7217729-B2 | Substituted indoles, process for the production thereof and use thereof for combatting pain | GRUNENTHAL GMBH (DE) | 2007-05-15 | — | — | US | disclosed |
| EP-1771417-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-04-11 | — | — | EP | disclosed |
| EP-1472221-B1 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | GRUENENTHAL GMBH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2006010577-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2006-02-02 | — | — | WO | disclosed |
| US-20040225003-A1 | 4,6-Dimethyl-3-{[3'-(N,N-dimethylaminomethyl)-4-hydroxy-4'-(3''-methoxyphenyl)-cyclohexylamino]-methyl}-1H-indole 2-carboxylic acid ethyl ester or other derivatives of substituted indoles; for treatment or prevention of neurodegenerative diseases, psychological disorders, AIDS, inflammation or allergies | GRUNENTHAL GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| EP-0192522-B1 | 1-ETHYL- 3-HYDROXY-3-PHENYLPIPERIDINE, PROCESS FOR ITS PREPARATION AND ITS THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-08-31 | — | — | EP | disclosed |
| US-4680302-A | ANTIDEPRESSANTS | LABORATOIRE L. LAFON (FR) | 1987-07-14 | — | — | US | disclosed |
| EP-0192522-A1 | 1-ethyl- 3-hydroxy-3-phenylpiperidine, process for its preparation and its therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040225003-A1 | 4,6-Dimethyl-3-{[3'-(N,N-dimethylaminomethyl)-4-hydroxy-4'-(3''-methoxyphenyl)-cyclohexylamino]-methyl}-1H-indole 2-carboxylic acid ethyl ester or other derivatives of substituted indoles; for treatment or prevention of neurodegenerative diseases, psychological disorders, AIDS, inflammation or allergies | HNMT, HTR6, HTR3C | OPRM1 287/4885OPRD1 319/4885OPRK1 76/4885 |
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | OPRK1, OPRD1, OPRL1 | OPRM1 4/4885OPRD1 2/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.