SCHEMBL30869434

SCHEMBL30869434

O=C(CCl)N1c2ccc(Br)cc2Oc2cc(Br)ccc21

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CASP2 P42575 1/20 0.45
NPC1 O15118 1/20 0.41
MITF O75030 1/20 0.41
RAB9A P51151 1/20 0.41
AHR P35869 3/20 0.41
P2RX4 Q99571 1/20 0.38
CUL4A Q13619 1/20 0.36
TERT O14746 1/20 0.35
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
MYC P01106 1/20 0.33
NR4A1 P22736 1/20 0.33
PKM P14618 1/20 0.33
RNF114 Q9Y508 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5241094 0.76 P2RX4 (0.65) NPC1MITFRAB9AP2RX4
SCHEMBL10953413 0.75 P2RX4 (0.40) NPC1MITFRAB9AP2RX4MAPT
SCHEMBL30869494 0.71 CUL4A (0.33) CASP2NPC1AHRCUL4AMAPT
SCHEMBL18216974 0.70 P2RX4 (0.36) NPC1MITFRAB9AP2RX4MAPT
SCHEMBL7643900 0.70 KMO (0.43) AHRCUL4AMAPTMYCNR4A1
SCHEMBL30869661 0.70 WNT1 (0.35) CUL4A
SCHEMBL24378120 0.68 SIRT1 (0.47) CASP2
SCHEMBL1929776 0.68 P2RX4 (0.49) NPC1MITFRAB9AP2RX4MAPT
SCHEMBL31314363 0.67 AHR (0.54) CASP2AHRCUL4AMAPTMYC
SCHEMBL31443280 0.67 AHR (0.48) AHRCUL4AMAPTSMN1; SMN2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070880-A1 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES, INC. (US) 2026-03-12 US disclosed
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070880-A1 DYNAMIN ACTIVATORS DNM1, DNM1L, DNM2 CASP2 2914/4885NPC1 58/4885MITF 2285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.