Sugi Predict

Sugi Predict / Compounds / SCHEMBL3088925

SCHEMBL3088925

SCHEMBL3088925

COc1ccc(-c2cccc(COC[C@@H]3C[C@@H](O)CN3C(=O)O)c2-c2ccc(OC)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 1/20 0.37
▸ FFAR4 Q5NUL3 1/20 0.37
▸ CD274 Q9NZQ7 4/20 0.35
▸ PDCD1 Q15116 2/20 0.35
▸ GRIA2 P42262 2/20 0.34
▸ GRIA4 P48058 2/20 0.34
▸ F10 P00742 2/20 0.34
▸ HDAC4 P56524 1/20 0.33
▸ HDAC2 Q92769 1/20 0.33
▸ HDAC8 Q9BY41 1/20 0.33
▸ KCNA5 P22460 1/20 0.33
▸ KCNH2 Q12809 1/20 0.33
▸ EDNRB P24530 1/20 0.33
▸ EDNRA P25101 1/20 0.33
▸ MMP2 P08253 3/20 0.33
▸ MMP9 P14780 3/20 0.33
▸ MMP12 P39900 2/20 0.33
▸ F2 P00734 1/20 0.33
▸ CHRM3 P20309 1/20 0.33
▸ MMP1 P03956 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6409694 0.78 FFAR4 (0.54) FFAR1FFAR4
SCHEMBL2997039 0.76 PDCD1 (0.31) CD274PDCD1GRIA2GRIA4
SCHEMBL4301223 0.75 NR1D1 (0.41) —
SCHEMBL6482211 0.75 FFAR4 (0.42) FFAR1FFAR4HDAC4HDAC2HDAC8
SCHEMBL4013903 0.75 ALK (0.35) FFAR1FFAR4HDAC4HDAC2HDAC8
SCHEMBL430965 0.73 ABL1 (0.46) FFAR1FFAR4HDAC4HDAC2HDAC8
SCHEMBL6408337 0.73 FFAR1 (0.40) FFAR1FFAR4HDAC4HDAC2HDAC8
SCHEMBL6474184 0.73 FFAR4 (0.40) FFAR1FFAR4HDAC4HDAC2HDAC8
SCHEMBL6473664 0.72 FFAR4 (0.39) FFAR1FFAR4HDAC4HDAC2HDAC8
SCHEMBL22555190 0.72 AGTR2 (0.46) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1430147-B1 FLUORESCENT QUENCHING DETECTION REAGENTS AND METHODS EPOCH BIOSCIENCES INC (US) 2013-05-22 — — EP disclosed
US-20100174058-A1 FLUORESCENT QUENCHING DETECTING REAGENTS AND METHODS ELITECHGROUP, INC. 2010-07-08 — — US disclosed
US-20040191796-A1 Fluorescent quenching detection reagents and methods EPOCH PHARMACEUTICALS, INC. (US) 2004-09-30 — — US disclosed
US-6790945-B2 OLIGONUCLEOTIDE PROBES CONTAINING TWO LABELS USEFUL IN HYBRIDIZATION ASSAYS EPOCH BIOSCIENCES, INC. 2004-09-14 — — US disclosed
US-20040081959-A9 Using oligonucleotide detectors; hybridization analyzing EPOCH BIOSCIENCES, INC. (US) 2004-04-29 — — US disclosed
US-6727356-B1 AS PROBES SUCH AS FOR FLUORESCENCE RESONANCE ENERGY TRANSFER; QUENCHER INCLUDES A 4-(PHENYLDIAZENYL)PHENYLAMINE STRUCTURE; IMPROVED SIGNAL TO NOISE RATIO AND HYBRIDIZATION EPOCH PHARMACEUTICALS, INC. 2004-04-27 — — US disclosed
US-6699975-B2 OLIGONUCLEOTIDE FOR USE AS TOOL IN THE DETECTION OF PREFERENTIAL COMPOUNDS IN SOLUTION EPOCH BIOSCIENCES, INC. 2004-03-02 — — US disclosed
US-6653473-B2 Nucleotide sequences for use as diagnostic tool in genetic analysis EPOCH BIOSCIENCES, INC. 2003-11-25 — — US disclosed
US-20030096254-A1 Enhancing resonance ability of oligonuclotide probes for use in hybridization assays; gene expression EPOCH BIOSCIENCES, INC. (US) 2003-05-22 — — US disclosed
US-20030008304-A1 Fluorescent quenching detection reagents and methods EPOCH BIOSCIENCES, INC. (US) 2003-01-09 — — US disclosed
US-20020155484-A1 Fluorescent quenching detection reagents and methods EPOCH PHARMACEUTICALS, INC. (US) 2002-10-24 — — US disclosed
US-20020034754-A1 Fluorescent quenching detection reagents and methods ELITECHGROUP, INC. 2002-03-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030008304-A1 Fluorescent quenching detection reagents and methods DDX5, DDX21, DCLRE1B FFAR1 4445/4885FFAR4 3756/4885CD274 4698/4885
US-20020034754-A1 Fluorescent quenching detection reagents and methods DDX5, DDX21, DCLRE1B FFAR1 4445/4885FFAR4 3756/4885CD274 4698/4885
US-20100174058-A1 FLUORESCENT QUENCHING DETECTING REAGENTS AND METHODS DDX5, DDX21, DCLRE1B FFAR1 4435/4885FFAR4 3897/4885CD274 4645/4885
US-20040081959-A9 Using oligonucleotide detectors; hybridization analyzing DCLRE1B, DDX21, DDX41 FFAR1 4718/4885FFAR4 4053/4885CD274 2591/4885
US-20020155484-A1 Fluorescent quenching detection reagents and methods IPO4, PTBP3, DDX5 FFAR1 4491/4885FFAR4 2141/4885CD274 2233/4885
US-20040191796-A1 Fluorescent quenching detection reagents and methods DDX5, IPO4, DBF4 FFAR1 4660/4885FFAR4 2543/4885CD274 2145/4885
US-20030096254-A1 Enhancing resonance ability of oligonuclotide probes for use in hybridization assays; gene expression DCLRE1B, SNRPE, ZFR FFAR1 4614/4885FFAR4 4555/4885CD274 4634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.