Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenol SCHEMBL309332 | 0.91 | TDP1 (0.61) | TSHRTDP1LMNAGAACES1 | |
| P-Nitrophenol SCHEMBL14125735 | 0.91 | TDP1 (0.61) | TSHRTDP1LMNAGAACES1 | |
| P-Nitrophenol SCHEMBL27462973 | 0.91 | TDP1 (0.60) | TSHRTDP1LMNAGAACES1 | |
| P-Nitrophenol SCHEMBL17289474 | 0.89 | TDP1 (0.59) | TSHRTDP1LMNAGAACES1 | |
| P-Nitrophenol SCHEMBL15203620 | 0.89 | ALDH1A1 (0.64) | TSHRTDP1LMNACES1ALDH1A1 | |
| P-Nitrophenol SCHEMBL11048842 | 0.89 | CES1 (0.58) | TSHRTDP1LMNAGAACES1 | |
| P-Nitrophenol SCHEMBL1839 | 0.89 | CES1 (0.58) | TSHRTDP1LMNAGAACES1 | |
| P-Nitrophenol SCHEMBL29806213 | 0.89 | CES1 (0.58) | TSHRTDP1LMNAGAACES1 | |
| P-Nitrophenol SCHEMBL692178 | 0.87 | MAPK1 (0.61) | TSHRTDP1LMNAGAACES1 | |
| P-Nitrophenol SCHEMBL64459 | 0.87 | ALDH1A1 (0.61) | TSHRTDP1LMNACES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12435090-B2 | Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use | REPARE THERAPEUTICS INC. (CA) | 2025-10-07 | — | — | US | disclosed |
| US-12116343-B2 | Inhibitors of APOL1 and methods of using same | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2024-10-15 | — | — | US | disclosed |
| CN-116348447-A | Inhibitors of APOL1 and methods of using the same | 弗特克斯药品有限公司 | 2023-06-27 | — | — | CN | disclosed |
| US-20230122909-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PREPARING COMPOUNDS AND OF THEIR USE | REPARE THERAPEUTICS INC. (CA) | 2023-04-20 | — | — | US | disclosed |
| EP-4097083-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | Vertex Pharmaceuticals Incorporated (US) | 2022-12-07 | — | — | EP | disclosed |
| US-20220340523-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED | 2022-10-27 | — | — | US | disclosed |
| WO-2021154997-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-08-05 | — | — | WO | disclosed |
| US-20190117680-A1 | DENDRIMERIC PLATFORM FOR CONTROLLED RELEASE OF DRUGS | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2019-04-25 | — | — | US | disclosed |
| US-20170080097-A1 | DENDRIMERIC PLATFORM FOR CONTROLLED RELEASE OF DRUGS | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2017-03-23 | — | — | US | disclosed |
| CN-104011021-B | heterocyclic derivatives and their use as prostaglandin D2 receptor modulators | 埃科特莱茵药品有限公司 | 2016-08-24 | — | — | CN | disclosed |
| WO-2012004722-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-01-12 | — | — | WO | disclosed |
| WO-2011030139-A1 | 4- (PYRIMIDIN-2-YL) -PIPERAZINE AND 4- (PYRIMIDIN-2-YL) -PIPERIDINE DERIVATIVES AS GPR119 MODULATORS | ASTRAZENECA AB (SE) | 2011-03-17 | — | — | WO | disclosed |
| US-20110065706-A1 | Therapeutic Agents 812 | ASTRAZENECA AB (SE) | 2011-03-17 | — | — | US | disclosed |
| US-20100105857-A1 | DENDRIMERIC PLATFORM FOR CONTROLLED RELEASE OF DRUGS | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD (IL) | 2010-04-29 | — | — | US | disclosed |
| EP-2081601-A1 | DENDRIMERIC PLATFORM FOR CONTROLLED RELEASE OF DRUGS | Ariel-University Research And Development Company, Ltd. (IL) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008047345-A1 | DENDRIMERIC PLATFORM FOR CONTROLLED RELEASE OF DRUGS | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2008-04-24 | — | — | WO | disclosed |
| US-7183319-B2 | Phenylethylamine derivatives and their use in the treatment of melanoma | RILEY PATRICK ANTHONY | 2007-02-27 | — | — | US | disclosed |
| US-20040029967-A1 | Phenylethylamine derivatives and their use in the treatment of melanoma | RILEY PATRICK ANTHONY (GB) | 2004-02-12 | — | — | US | disclosed |
| EP-1303481-A1 | PHENYLETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MELANOMA | Riley, Patrick Anthony (GB) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008174-A1 | PHENYLETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MELANOMA | RILEY PATRICK ANTHONY (GB) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340523-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, APOB, NPC1L1 | TSHR 3789/4885TDP1 1982/4885LMNA 1071/4885 |
| US-12116343-B2 | Inhibitors of APOL1 and methods of using same | APOL1, APOB, NPC1L1 | TSHR 3789/4885TDP1 1982/4885LMNA 1071/4885 |
| US-20230122909-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PREPARING COMPOUNDS AND OF THEIR USE | PLK1, CSNK1A1, CSNK1G1 | TSHR 2951/4885TDP1 677/4885LMNA 2090/4885 |
| US-20190117680-A1 | DENDRIMERIC PLATFORM FOR CONTROLLED RELEASE OF DRUGS | CCL2, CD63, CD69 | TSHR 1614/4885TDP1 4335/4885LMNA 2024/4885 |
| US-12435090-B2 | Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use | PLK1, CSNK1A1, CSNK1G1 | TSHR 2951/4885TDP1 677/4885LMNA 2090/4885 |
| US-20110065706-A1 | Therapeutic Agents 812 | GPR119, GPR84, GPR132 | TSHR 957/4885TDP1 4678/4885LMNA 4102/4885 |
| US-20170080097-A1 | DENDRIMERIC PLATFORM FOR CONTROLLED RELEASE OF DRUGS | CCL2, CD63, CD69 | TSHR 1614/4885TDP1 4335/4885LMNA 2024/4885 |
| US-20040029967-A1 | Phenylethylamine derivatives and their use in the treatment of melanoma | DOHH, DBH, HRH4 | TSHR 538/4885TDP1 2119/4885LMNA 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.