Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3094031 | 1.00 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL14735934 | 0.85 | HSD11B1 (0.46) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL14735933 | 0.85 | HSD11B1 (0.46) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL16534558 | 0.82 | SNCA (0.48) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL901262 | 0.82 | ERN1 (0.53) | ALDH1A1MEN1KMT2AMAPTERN1 | |
| SCHEMBL901263 | 0.82 | ERN1 (0.53) | ALDH1A1MEN1KMT2AMAPTERN1 | |
| SCHEMBL3085486 | 0.79 | ERN1 (0.50) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL3085483 | 0.79 | ERN1 (0.50) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL13646956 | 0.79 | ERN1 (0.50) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL25540386 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| EP-4015519-A1 | METHOD OF PREPARING ASENAPINE | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021027813-A1 | METHOD OF PREPARING ASENAPINE | 浙江奥翔药业股份有限公司 | 2021-02-18 | — | — | WO | disclosed |
| US-8227623-B2 | Process for the preparation of asenapine and intermediate products used in said process | MSD OSS B.V. (NL) | 2012-07-24 | — | — | US | disclosed |
| US-8227623-B2 | Process for the preparation of asenapine and intermediate products used in said process | MSD OSS B.V. (NL) | 2012-07-24 | — | — | US | disclosed |
| US-8227623-B2 | Process for the preparation of asenapine and intermediate products used in said process | MSD OSS B.V. (NL) | 2012-07-24 | — | — | US | disclosed |
| US-20100234618-A1 | Process for the Preparation of Asenapine and Intermediate Products Used in Said Process | N.V. ORGANON (NL) | 2010-09-16 | — | — | US | disclosed |
| US-20100234618-A1 | Process for the Preparation of Asenapine and Intermediate Products Used in Said Process | N.V. ORGANON (NL) | 2010-09-16 | — | — | US | disclosed |
| US-20100234618-A1 | Process for the Preparation of Asenapine and Intermediate Products Used in Said Process | N.V. ORGANON (NL) | 2010-09-16 | — | — | US | disclosed |
| US-7750167-B2 | Process for the preparation of asenapine and intermediate products used in said process | N.V. ORGANON (NL) | 2010-07-06 | — | — | US | disclosed |
| US-7750167-B2 | Process for the preparation of asenapine and intermediate products used in said process | N.V. ORGANON (NL) | 2010-07-06 | — | — | US | disclosed |
| US-7750167-B2 | Process for the preparation of asenapine and intermediate products used in said process | N.V. ORGANON (NL) | 2010-07-06 | — | — | US | disclosed |
| EP-2044076-B1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | ORGANON NV (NL) | 2009-10-14 | — | — | EP | disclosed |
| EP-2044076-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | N.V. Organon (NL) | 2009-04-08 | — | — | EP | disclosed |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2008-01-10 | — | — | US | disclosed |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2008-01-10 | — | — | US | disclosed |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2008-01-10 | — | — | US | disclosed |
| WO-2008003460-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | N.V. ORGANON (NL) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008003460-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | N.V. ORGANON (NL) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | CYP3A5, QDPR, SPR | ALDH1A1 1362/4885MEN1 2222/4885KMT2A 2211/4885 |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | DHPS, CYP3A5, PNMT | ALDH1A1 600/4885MEN1 4096/4885KMT2A 1335/4885 |
| US-20100234618-A1 | Process for the Preparation of Asenapine and Intermediate Products Used in Said Process | DHPS, CYP3A5, PNMT | ALDH1A1 600/4885MEN1 4096/4885KMT2A 1335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.